Cornelissen M, Smeets D, Merkx G, De Abreu R, Kollee L, Monnens L
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Pediatr Res. 1991 Dec;30(6):550-3. doi: 10.1203/00006450-199112000-00011.
In many countries vitamin K prophylaxis at birth is recommended to prevent bleeding in infants due to vitamin K deficiency. Because the incidence of clinical vitamin K deficiency is very low, such a vitamin K administration should be completely safe. However, an increase in sister chromatid exchanges in lymphocytes of fetal sheep 24 h after injection of vitamin K1 has been reported. Therefore, a study concerning genotoxicity of vitamin K1 in man was conducted. Sister chromatid exchanges and chromosome aberrations were analyzed in peripheral blood lymphocytes of six newborns 24 h after intramuscular administration of 1 mg vitamin K1 and in six control neonates. The mean number of sister chromatid exchanges per metaphase in the vitamin K group was 8.88 +/- 1.22 as compared with 9.05 +/- 1.14 in the control group (NS). The mean number of chromosome aberrations per 100 mitoses was 3.00 +/- 2.61 in the vitamin K group and 2.50 +/- 1.87 in the control group (NS). Vitamin K1 plasma concentrations ranged from 115 to 1150 ng/mL (255 to 2555 x 10(-9) M) in the supplemented group, a 5000-fold rise as compared with the control group (p less than 0.01). We did not find any evidence for genetic toxicity due to the administration of 1 mg vitamin K1 intramuscularly to the newborn child.
在许多国家，建议在出生时进行维生素K预防，以防止婴儿因维生素K缺乏而出血。由于临床维生素K缺乏的发生率很低，这种维生素K的给药应该是完全安全的。然而，有报道称，给胎羊注射维生素K1后24小时，其淋巴细胞中的姐妹染色单体交换增加。因此，开展了一项关于维生素K1对人体遗传毒性的研究。在6名新生儿肌肉注射1毫克维生素K1后24小时，分析其外周血淋巴细胞中的姐妹染色单体交换和染色体畸变情况，并与6名对照新生儿进行比较。维生素K组每个中期的姐妹染色单体交换平均数为8.
