Kulkarni P S, Mondkar V P, Sonawalla A B, Ambani L M
Food Chem Toxicol. 1984 Dec;22(12):1009-12. doi: 10.1016/0278-6915(84)90151-0.
Chromosome studies were carried out on the peripheral blood of 26 epilepsy patients treated with phenobarbital and/or diphenylhydantoin, on ten healthy controls and on eight untreated epileptic controls. There was a significant increase in the individual numbers of sister chromatid exchanges per metaphase for all the patients treated with drugs compared with the mean of the pooled values from all the controls. There was no significant increase in the number of chromosome aberrations in the treated patients compared with the controls. There were very few structural aberrations in either the treated patients or the controls.
对26名接受苯巴比妥和/或苯妥英治疗的癫痫患者、10名健康对照者以及8名未经治疗的癫痫对照者的外周血进行了染色体研究。与所有对照者合并值的平均值相比，所有接受药物治疗的患者每个中期的姐妹染色单体交换个体数量显著增加。与对照者相比，接受治疗的患者染色体畸变数量没有显著增加。治疗患者和对照者中结构畸变都很少。
