Qiu Haowen, Checketts Rees, Jackson Mariah Kay, Riethoven Jean-Jack M, Hansel Nadia N, Bailey Kristina L, Hanson Corrine, Samuelson Derrick R
Bioinformatics Core Research Facility, Nebraska Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Department of Internal Medicine, Internal Medicine Residency Program, Creighton University Medicine Center, Omaha, NE, USA.
Front Microbiomes. 2024;3. doi: 10.3389/frmbi.2024.1426150. Epub 2024 Oct 21.
Chronic Obstructive Pulmonary Disease (COPD) affects 30 million Americans. Previous epidemiologic work has shown that diet can impact pulmonary function in those with and without COPD. Diet is also a major driver of gut microbiome composition and function. Importantly, the gut microbiome has also been associated with lung health (i.e., the gut-lung axis) in both preclinical and clinical studies. Despite this growing body of evidence, many questions remain regarding the gut-lung axis. Specifically, how the microbiome impacts the relationship between diet factors and spirometry or stage of disease in people with COPD is little understood. We hypothesize that there are taxonomic differences in the gut microbiome among the different stages of COPD and that diet microbiome interactions influence pulmonary function. This study aimed to identify how the GI microbiota correlated with the severity of respiratory disease in COPD patients and how the microbiome may mediate the relationship between diet, including fiber and omega-3 fatty acids, and lung function outcomes.
慢性阻塞性肺疾病（COPD）影响着3000万美国人。先前的流行病学研究表明，饮食会影响患有和未患有COPD的人的肺功能。饮食也是肠道微生物群组成和功能的主要驱动因素。重要的是，在临床前和临床研究中，肠道微生物群也与肺部健康（即肠-肺轴）有关。尽管有越来越多的证据，但关于肠-肺轴仍有许多问题。具体而言，微生物群如何影响COPD患者饮食因素与肺活量测定或疾病阶段之间的关系，目前还知之甚少。我们假设，COPD不同阶段的肠道微生物群存在分类学差异，并且饮食与微生物群的相互作用会影响肺功能。本研究旨在确定胃肠道微生物群如何与COPD患者呼吸系统疾病严重程度相关，以及微生物群如何介导饮食（包括纤维和ω-3脂肪酸）与肺功能结果之间的关系。
