Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia.
Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.
Nutrients. 2022 Aug 18;14(16):3384. doi: 10.3390/nu14163384.
Obesity is a problem of modern health care that causes the occurrence of many concomitant diseases: arterial hypertension, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. New strategies for the treatment and prevention of obesity are being developed that are based on using probiotics for modulation of the gut microbiota. Our study aimed to evaluate the bacterial composition of the gut of obese patients before and after two weeks of lactic acid bacteria (, , , and ) intake. The results obtained showed an increase in the number of members of the phylum Actinobacteriota in the group taking nutritional supplements, while the number of phylum Bacteroidota decreased in comparison with the control group. There has also been an increase in potentially beneficial groups: , , , , , , , , and . Along with this, a decrease in the genera was demonstrated: , , , , and , , , , and the group, which contribute to the development of various metabolic disorders. Modulation of the gut microbiota by lactic acid bacteria may be one of the ways to treat obesity.
肥胖是现代医疗保健中的一个问题，它会导致许多伴随疾病的发生：动脉高血压、糖尿病、非酒精性脂肪肝和心血管疾病。目前正在开发新的肥胖治疗和预防策略，这些策略基于使用益生菌来调节肠道微生物群。我们的研究旨在评估肥胖患者在两周内摄入乳酸杆菌（、、、和）前后肠道的细菌组成。结果表明，在服用营养补充剂的组中，厚壁菌门的成员数量增加，而与对照组相比，拟杆菌门的数量减少。潜在有益的群组也有所增加：、、、、、、、、和。与此相伴的是，一些属的数量减少：、、、、、、、、和 ，这些属会导致各种代谢紊乱。通过乳酸杆菌调节肠道微生物群可能是治疗肥胖的方法之一。
