Deng Min, Farahani Kiana, Agak George W
Division of Dermatology, David Geffen School of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA.
Cell Signal (Middlet). 2025;3(1):32-39. doi: 10.46439/signaling.3.053.
The comprehensive changes and shared dysregulated signaling pathways in early stage acne remains largely unexplored. In our recently published paper entitled "," we utilized single-cell RNA sequencing and spatial transcriptomics datasets from acne patients to analyze cell communication. We identified dysregulated genes linked to inflammatory responses and hyperkeratinization. This commentary discusses potential new markers across major skin cell types, including endothelial cells, fibroblasts, lymphocytes, myeloid cells, keratinocytes, and smooth muscle cells. Additionally, we discuss key dysregulated genes in acne lesions, focusing on the intricate interplay between inflammation and hyperkeratinization. Based on our findings, we explore potential FDA-approved treatments targeting two key pathways involved in acne pathogenesis. These insights provide new therapeutic targets for acne treatment.
早期痤疮的全面变化和共同失调的信号通路在很大程度上仍未得到充分探索。在我们最近发表的题为《》的论文中，我们利用痤疮患者的单细胞RNA测序和空间转录组学数据集来分析细胞通讯。我们鉴定出了与炎症反应和过度角化相关的失调基因。本评论讨论了主要皮肤细胞类型（包括内皮细胞、成纤维细胞、淋巴细胞、髓样细胞、角质形成细胞和平滑肌细胞）中潜在的新标志物。此外，我们讨论了痤疮病变中的关键失调基因，重点关注炎症和过度角化之间的复杂相互作用。基于我们的发现，我们探索了针对痤疮发病机制中两个关键途径的潜在FDA批准的治疗方法。这些见解为痤疮治疗提供了新的治疗靶点。
