Satapathy Nishant, Movahed Mohammad Reza
University of Arizona College of Medicine-Phoenix Phoenix, AZ 85004, USA.
University of Arizona Sarver Heart Center Tucson, AZ 85724, USA.
Am J Cardiovasc Dis. 2025 Apr 25;15(2):115-122. doi: 10.62347/LPLW4777. eCollection 2025.
The effect of gender on outcome in post-cardiac transplant morbidity and mortality including the occurrence of transplant vasculopathy is not well established. The goal of this study was to evaluate adverse post-transplant outcomes based on gender with a focus on cardiac allograft vasculopathy (CAV).
Using our post-transplant database at the University of Arizona, the effect of gender after heart transplantation on death, major adverse cardiac events (MACE defined as the combined occurrence of myocardial infarction, percutaneous coronary intervention, coronary bypass surgery, re-transplantation, and death) and the occurrence of CAV was evaluated retrospectively over 3 years.
A total of 149 patients were evaluated in our database. Over the study period after the first year post-transplantation, a total of 4,7% deaths occurred. There were no differences in death between males and females (4.3% vs 6.1%, p = ns). MACE occurred in similar degrees between males and females (7.8% vs 9.1%, p = ns). Furthermore, the occurrence of an abnormal coronary angiogram or significant intima thickening seen during intracoronary ultrasound studies was similar between the genders for every year studied.
Gender does not effect on the occurrence of CAV at any year's post-cardiac transplantation. Furthermore, it has no effect on MACE and mortality.
性别对心脏移植后发病率、死亡率（包括移植血管病变的发生）的影响尚未明确。本研究的目的是基于性别评估移植后的不良结局，重点关注心脏同种异体移植血管病变（CAV）。
利用亚利桑那大学的移植后数据库，对心脏移植后性别对死亡、主要不良心脏事件（MACE，定义为心肌梗死、经皮冠状动脉介入治疗、冠状动脉搭桥手术、再次移植和死亡的综合发生）以及CAV发生的影响进行了为期3年的回顾性评估。
我们的数据库共评估了149例患者。在移植后第一年之后的研究期间，共有4.7%的患者死亡。男性和女性的死亡率无差异（4.3%对6.1%，p=无统计学意义）。男性和女性发生MACE的程度相似（7.8%对9.1%，p=无统计学意义）。此外，在每年的研究中，冠状动脉造影异常或冠状动脉内超声检查中发现的显著内膜增厚在两性之间相似。
性别在心脏移植后的任何年份均不影响CAV的发生。此外，它对MACE和死亡率也没有影响。
