Guagliardo Sarah Anne J, Martin Stacey, Gould Carolyn V, Sutter Rebekah, Jacobs Daniel, O'Laughlin Kevin, Huits Ralph, Castilletti Concetta, Staples J Erin
Emerg Infect Dis. 2025 Jul;31(7):1337-1343. doi: 10.3201/eid3107.250468. Epub 2025 May 22.
Determining the incubation period of Oropouche virus disease can inform clinical and public health practice. We analyzed data from 97 travel-associated cases identified by the Centers for Disease Control and Prevention (n = 74) or the GeoSentinel Network (n = 13) and 10 cases from published literature. Using log-normal interval-censored survival analysis, we estimated the median incubation period to be 3.2 (95% CI 2.5-3.9) days. Symptoms developed by 1.1 (95% CI 0.6-1.5) days for 5% of patients, 9.7 (95% CI 6.9-12.5) days for 95% of patients, and 15.4 (95% CI 9.6-21.3) days for 99% of patients. The estimated incubation period range of 1-10 days can be used to assess timing and potential source of exposure in patients with Oropouche symptoms. For patients with symptom onset >2 weeks after return from travel, clinicians and public health responders should consider the possibility of local vectorborne transmission or alternative modes of transmission.
确定奥罗普切病毒病的潜伏期可为临床和公共卫生实践提供参考。我们分析了美国疾病控制与预防中心（n = 74）或全球监测网络（n = 13）确定的97例与旅行相关病例的数据以及已发表文献中的10例病例。通过对数正态区间删失生存分析，我们估计中位潜伏期为3.2天（95%置信区间2.5 - 3.9天）。5%的患者在1.1天（95%置信区间0.6 - 1.5天）出现症状，95%的患者在9.7天（95%置信区间6.9 - 12.5天）出现症状，99%的患者在15.4天（95%置信区间9.6 - 21.3天）出现症状。估计的1 - 10天潜伏期范围可用于评估出现奥罗普切症状患者的暴露时间和潜在暴露源。对于旅行归来2周后出现症状的患者，临床医生和公共卫生响应人员应考虑本地媒介传播或其他传播方式的可能性。
