MMWR Morb Mortal Wkly Rep. 2024 Sep 5;73(35):769-773. doi: 10.15585/mmwr.mm7335e1.
Beginning in late 2023, Oropouche virus was identified as the cause of large outbreaks in Amazon regions with known endemic transmission and in new areas in South America and the Caribbean. The virus is spread to humans by infected biting midges and some mosquito species. Although infection typically causes a self-limited febrile illness, reports of two deaths in patients with Oropouche virus infection and vertical transmission associated with adverse pregnancy outcomes have raised concerns about the threat of this virus to human health. In addition to approximately 8,000 locally acquired cases in the Americas, travel-associated Oropouche virus disease cases have recently been identified in European travelers returning from Cuba and Brazil. As of August 16, 2024, a total of 21 Oropouche virus disease cases were identified among U.S. travelers returning from Cuba. Most patients initially experienced fever, myalgia, and headache, often with other symptoms including arthralgia, diarrhea, nausea or vomiting, and rash. At least three patients had recurrent symptoms after the initial illness, a common characteristic of Oropouche virus disease. Clinicians and public health jurisdictions should be aware of the occurrence of Oropouche virus disease in U.S. travelers and request testing for suspected cases. Travelers should prevent insect bites when traveling, and pregnant persons should consider deferring travel to areas experiencing outbreaks of Oropouche virus disease.
自 2023 年末以来，奥罗普切病毒已被确定为导致亚马逊地区已知地方性传播地区以及南美洲和加勒比地区新出现地区大规模暴发的原因。该病毒通过受感染的吸血蠓和一些蚊子传播给人类。虽然感染通常会导致自限性发热疾病，但有两例奥罗普切病毒感染患者死亡的报告以及与不良妊娠结局相关的垂直传播，引起了人们对该病毒对人类健康威胁的关注。除了美洲约 8000 例本地获得性病例外，最近在从古巴和巴西返回的欧洲旅行者中发现了与旅行相关的奥罗普切病毒病病例。截至 2024 年 8 月 16 日，从古巴返回的美国旅行者中总共发现了 21 例奥罗普切病毒病病例。大多数患者最初出现发热、肌肉疼痛和头痛，常伴有其他症状，包括关节痛、腹泻、恶心或呕吐和皮疹。至少有三名患者在初次发病后出现了反复症状，这是奥罗普切病毒病的一个常见特征。临床医生和公共卫生部门应意识到美国旅行者中出现奥罗普切病毒病，并要求对疑似病例进行检测。旅行者在旅行时应防止蚊虫叮咬，孕妇应考虑推迟前往发生奥罗普切病毒病暴发的地区旅行。
