Karhana Sonali, Khan Mohd Ashif
Department of Translational & Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
Dermatol Pract Concept. 2025 Apr 1;15(2):4945. doi: 10.5826/dpc.1502a4945.
A systematic review was conducted to investigate the efficacy of acellular fish skin grafts (AFSGs) for the treatment of complicated wounds. AFSGs can be used as a regenerative and antimicrobial tool for healing complicated wounds, but clinical evidence remains unclear.
This systematic review aimed to summarize the efficacy of AFSGs on complicated wounds using evidence from existing published studies.
Electronic databases like PubMed, ScienceDirect, Google Scholar, and Clinicaltrials.gov were searched for relevant literature reporting on the efficacy of AFSGs for wound healing. Based on the inclusion and exclusion criteria, nine studies were selected for data extraction. The quality of the articles was evaluated using the RoB 2 and ROBINS-I tools.
Existing evidence shows that AFSGs accelerate wound healing, reduce pain, prevent antibiotic administration, and cause no autoimmune reactions. The total re-epithelialization time for diabetic foot ulcers (DFUs) was observed as 15 ± 8 weeks, depending on the severity of the ulcers. Acute full thickness biopsy wounds healed within 3.75 ± 0.25 weeks. As reported in papers, AFSGs showed significantly better effects than standard-of-care therapy, collagen alginate dressings, dehydrated human AMNION/chorion membrane, and/ or porcine small-intestine submucosa. However, instances of rashes, erythema, pain, and hypergranulation were reported when AFSGs were applied to biopsy wounds.
Overall, the evidence obtained in this systematic review indicates that AFSGs represent a clinically and financially effective option for the treatment of wounds when compared with conventional alternatives.
进行了一项系统综述，以研究脱细胞鱼皮移植物（AFSGs）治疗复杂伤口的疗效。AFSGs可作为一种促进复杂伤口愈合的再生和抗菌工具，但临床证据仍不明确。
本系统综述旨在利用现有已发表研究的证据，总结AFSGs对复杂伤口的疗效。
检索了PubMed、ScienceDirect、谷歌学术和Clinicaltrials.gov等电子数据库，以查找有关AFSGs促进伤口愈合疗效的相关文献。根据纳入和排除标准，选择了9项研究进行数据提取。使用RoB 2和ROBINS-I工具评估文章质量。
现有证据表明，AFSGs可加速伤口愈合、减轻疼痛、避免使用抗生素，且不会引起自身免疫反应。根据溃疡的严重程度，观察到糖尿病足溃疡（DFUs）的完全再上皮化总时间为15±8周。急性全层活检伤口在3.75±0.25周内愈合。正如论文中所报道的，AFSGs的效果明显优于标准护理疗法、胶原藻酸盐敷料、脱水人羊膜/绒毛膜和/或猪小肠黏膜下层。然而，当AFSGs应用于活检伤口时，有皮疹、红斑、疼痛和肉芽组织增生的报道。
总体而言，本系统综述获得的证据表明，与传统替代方案相比，AFSGs是一种在临床和经济上均有效的伤口治疗选择。
