Ibrahim Mohamed, Ayyoubi Haneen S, Alkhairi Layth A, Tabbaa Hozaifa, Elkins Isaac, Narvel Ravish
College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
Internal Medicine, Barry University, St. Petersburg, USA.
Cureus. 2023 Mar 19;15(3):e36348. doi: 10.7759/cureus.36348. eCollection 2023 Mar.
Wound healing poses a variety of challenges making it a vital subject in medicine. With the advancement of science, we have seen the use of a new xenograft known as acellular fish skin (AFS) grafts that are derived from either Atlantic cod or Nile Tilapia. Fish skin has shown anti-inflammatory and anti-bacterial properties that support and improve wound healing in a variety of wounds including burns and diabetic foot ulcers (DFU). There is ongoing research that evaluates the efficacy of fish skin grafts in comparison to alternative wound healing techniques. A literature search was conducted through the National Library of Medicine with search terms fish skin graft, AFS, xenograft, dehydrated human amnion/chorion, ulcer, burns, and wounds. A total of ten studies that investigate the efficacy of fish skin grafts either in comparison to a different wound healing technique or by simply observing wound healing with fish skin grafts and recording the results were chosen. AFS showed superior healing in comparison to collagen alginate dressings, silver sulfadiazine cream 1%, and allografts. Although there is no one specific gold standard technique for wound healing, fish skin grafts demonstrated overall improved and quicker wound healing, fewer dressing changes, less pain, and lower costs.
伤口愈合带来了各种各样的挑战，使其成为医学中的一个重要课题。随着科学的进步，我们看到了一种名为脱细胞鱼皮（AFS）移植物的新型异种移植物的应用，这种移植物取自大西洋鳕鱼或尼罗罗非鱼。鱼皮已显示出抗炎和抗菌特性，可支持和促进包括烧伤和糖尿病足溃疡（DFU）在内的各种伤口的愈合。目前正在进行研究，以评估鱼皮移植物与其他伤口愈合技术相比的疗效。通过美国国立医学图书馆进行了文献检索，检索词为鱼皮移植物、AFS、异种移植物、脱水人羊膜/绒毛膜、溃疡、烧伤和伤口。总共选择了十项研究，这些研究要么将鱼皮移植物的疗效与不同的伤口愈合技术进行比较，要么通过简单观察鱼皮移植物的伤口愈合情况并记录结果来进行。与藻酸胶原敷料、1%磺胺嘧啶银乳膏和同种异体移植物相比，AFS显示出更好的愈合效果。虽然没有一种特定的伤口愈合金标准技术，但鱼皮移植物总体上显示出伤口愈合得到改善且更快，换药次数减少，疼痛减轻，成本降低。
