Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
Department of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China.
J Diabetes. 2024 May;16(5):e13554. doi: 10.1111/1753-0407.13554.
Diabetic wounds cannot undergo normal wound healing due to changes in the concentration of hyperglycemia in the body and soon evolve into chronic wounds causing amputation or even death of patients. Diabetic wounds directly affect the quality of patients and social medical management; thus researchers started to focus on skin transplantation technology. The acellular fish skin grafts (AFSGs) are derived from wild fish, which avoids the influence of human immune function and the spread of the virus through low-cost decellularization. AFSGs contain a large amount of collagen and omega-3 polyunsaturated fatty acids and they have an amazing effect on wound regeneration. However, after our search in major databases, we found that there were few research trials in this field, and only one was clinically approved. Therefore, we summarized the advantages of AFSGs and listed the problems faced in clinical use. The purpose of this paper is to enable researchers to better carry out original experiments at various stages.
糖尿病伤口由于体内高血糖浓度的变化而无法进行正常的伤口愈合，很快就会演变成慢性伤口，导致患者截肢甚至死亡。糖尿病伤口直接影响患者的生活质量和社会医疗管理，因此研究人员开始关注皮肤移植技术。去细胞鱼皮移植物（AFSGs）来源于野生鱼类，通过低成本的去细胞化避免了人类免疫功能的影响和病毒的传播。AFSGs 含有大量的胶原蛋白和欧米伽-3 多不饱和脂肪酸，对伤口再生有惊人的效果。然而，在我们对各大数据库进行检索后发现，该领域的研究试验很少，仅有一项被临床批准。因此，我们总结了 AFSGs 的优势，并列出了在临床应用中面临的问题。本文的目的是使研究人员能够在各个阶段更好地进行原创实验。
