Azzolina Vanessa, Schauer Franziska, Pilz Julia Felicitas, Zink Alexander, Eyerich Kilian, Pilz Anna Caroline
Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg, Germany.
Department of Dermatology and Allergy, Technical University of Munich, School of Medicine and Health, Munich, Germany.
Dermatol Pract Concept. 2025 Apr 1;15(2):5077. doi: 10.5826/dpc.1502a5077.
Scabies is a parasitic infectious skin disease classified as a neglected tropical disease by the World Health Organization in 2017. Currently, it is becoming a major challenge in high-income countries, with rapidly rising incidence and increasing reports about treatment failure.
Factors that are associated with treatment failure or success were evaluated.
This non-interventional prospective observational study was conducted as a questionnaire survey at the Department of Dermatology and Venereology of the University of Freiburg from January to November 2023. Patients that still suffered from scabies 2-6 weeks after medical treatment were classified as "failure"; those who were free of scabies belonged to the success group.
Of 102 participants, with a mean age of 34.4 ± 17.3 years (male: 60.4%), 77 (75.5%) were assigned to the success and 25 (24.5%) to the failure group. A larger proportion of the latter was clinically more severely affected, applied permethrin monotherapy, did not undertake special decontamination measures, but used alcohol as a disinfectant. Treatment success was associated with an additional systemic treatment, a repeated intake of ivermectin, and intensified decontamination measures such as storage of clothes in plastic bags for four days or vacuum cleaning of car seats.
Our findings indicate that a consistent second-dose administration of ivermectin and refraining from permethrin monotherapy may be advisable.
疥疮是一种寄生虫感染性皮肤病，2017年被世界卫生组织列为被忽视的热带病。目前，它在高收入国家正成为一项重大挑战，发病率迅速上升，治疗失败的报告也日益增多。
评估与治疗失败或成功相关的因素。
这项非干预性前瞻性观察研究于2023年1月至11月在弗莱堡大学皮肤科和性病科以问卷调查的形式进行。治疗后2至6周仍患有疥疮的患者被归类为“失败”组；无疥疮的患者属于成功组。
102名参与者的平均年龄为34.4±17.3岁（男性占60.4%），其中77人（75.5%）被归入成功组，25人（24.5%）被归入失败组。失败组中较大比例的患者临床症状更严重，采用了氯菊酯单一疗法，未采取特殊的去污措施，但使用酒精作为消毒剂。治疗成功与额外的全身治疗、重复服用伊维菌素以及强化去污措施有关，如将衣物装在塑料袋中存放四天或对汽车座椅进行真空清洁。
我们的研究结果表明，伊维菌素持续给予第二剂以及避免使用氯菊酯单一疗法可能是可取的。
