Bengolea Agustin, Ruiz Juan I, Vega Celina G, Manzotti Matias, Zuccarino Nadia, Rey-Ares Lucila
Servicio de Clínica Médica, Hospital Alemán, Ciudad de Buenos Aires, Argentina.
Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
PLoS One. 2025 May 22;20(5):e0324735. doi: 10.1371/journal.pone.0324735. eCollection 2025.
To describe the hospital medical resources used in adults hospitalized with respiratory syncytial virus infection and to evaluate the association of comorbidities with resource utilization and clinical outcomes.
A retrospective cohort study was conducted using the electronic healthcare database of Hospital Alemán, Buenos Aires, Argentina. It included hospitalized patients aged 18 years or older who had a positive test for respiratory syncytial virus between September 2010 and December 2023. Data were analyzed using standard statistical methods following STROBE guidelines.
Among 72 hospitalized adults with confirmed respiratory syncytial virus infection, the mean length of hospital stay was 12.18 days (SD 12.91), and 27 (37.5%) patients required intensive care unit admission. Healthcare resource utilization was substantial, with 26% needing non-invasive ventilation and 11% requiring mechanical ventilation. Antibiotics (75%) and corticosteroids (68.05%) were commonly used, likely reflecting the severity of clinical presentation or the potential for bacterial coinfection. Cardiovascular comorbidities were significantly associated with severe disease outcomes and intensive care unit admission (OR 3.53, 95% CI: 1.00-12.54). Comparative analysis with 226 influenza patients showed respiratory syncytial virus patients had longer hospital stays and higher intensive care unit admission rates.
Respiratory syncytial virus infection in adults resulted in substantial medical resource utilization and significant intensive care unit admission and ventilation support requirements. Cardiovascular comorbidities might be associated with increased severity and intensive care unit admissions. The high rate of antibiotic use is noteworthy and warrants further investigation to understand prescribing patterns and optimize antimicrobial stewardship. Compared to influenza, respiratory syncytial virus appears to be associated with longer hospital stays and higher intensive care unit admissions, highlighting the need for tailored management strategies for respiratory syncytial virus in adult populations. Further research should focus on optimizing treatment protocols and preventive measures for respiratory syncytial virus.
描述因呼吸道合胞病毒感染住院的成人所使用的医院医疗资源，并评估合并症与资源利用及临床结局之间的关联。
使用阿根廷布宜诺斯艾利斯德国医院的电子医疗数据库进行了一项回顾性队列研究。研究纳入了2010年9月至2023年12月期间呼吸道合胞病毒检测呈阳性的18岁及以上住院患者。按照STROBE指南使用标准统计方法对数据进行分析。
在72例确诊为呼吸道合胞病毒感染的住院成人中，平均住院时间为12.18天（标准差12.91），27例（37.5%）患者需要入住重症监护病房。医疗资源利用情况较为显著，26%的患者需要无创通气，11%的患者需要机械通气。抗生素（75%）和皮质类固醇（68.05%）被普遍使用，这可能反映了临床表现的严重程度或细菌合并感染的可能性。心血管合并症与严重疾病结局和入住重症监护病房显著相关（比值比3.53，95%置信区间：1.00 - 12.54）。与226例流感患者的比较分析显示，呼吸道合胞病毒感染患者的住院时间更长，入住重症监护病房的比例更高。
成人呼吸道合胞病毒感染导致大量医疗资源的利用，以及显著的重症监护病房入住率和通气支持需求。心血管合并症可能与病情加重和重症监护病房入住率增加有关。抗生素的高使用率值得关注，有必要进一步调查以了解用药模式并优化抗菌管理。与流感相比，呼吸道合胞病毒似乎与更长的住院时间和更高的重症监护病房入住率相关，这凸显了针对成人呼吸道合胞病毒制定个性化管理策略的必要性。进一步的研究应聚焦于优化呼吸道合胞病毒的治疗方案和预防措施。
