Respiratory Infections Unit, Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Medizinische Fakultät Charité - Universitätsmedizin, Berlin, Germany.
Influenza Other Respir Viruses. 2020 Nov;14(6):658-670. doi: 10.1111/irv.12729. Epub 2020 Feb 16.
Respiratory syncytial virus (RSV) is a major cause of hospital admission for acute lower respiratory tract infection in young children.
We aimed to identify risk factors for hospitalized RSV disease and its severe outcomes.
We conducted a retrospective cohort study analyzing data of a ICD-10-code-based hospital surveillance for severe acute respiratory infections (SARI). Using univariable and multivariable logistic regression analysis, we assessed age-group, gender, season, and underlying medical conditions as possible risk factors for RSV and its severe outcomes including ICU admission, application of ventilator support, and death, respectively.
Of the 413 552 patients hospitalized with SARI in the database, 8761 were diagnosed with RSV from week 01/2009 to 20/2018 with 97% (8521) aged <5 years. Among children aged <5 years, age-groups 0-5 months (OR: 20.29, 95% CI: 18.37-22.41) and 6 months-1 year (OR: 4.59, 95% CI: 4.16-5.06), and underlying respiratory and cardiovascular disorders specific to the perinatal period (OR: 1.32, 95% CI: 1.11-1.57) were risk factors for being diagnosed with RSV. Age-group 0-5 months (OR: 2.39, 95% CI: 1.45-3.94), low birth weight (OR: 6.77, 95% CI: 1.28-35.71), preterm newborn (OR: 6.71, 95% CI: 2.19-20.61), underlying respiratory and cardiovascular disorders specific to the perinatal period (OR: 4.97, 95% CI: 3.36-7.34), congenital malformation of the heart (OR: 3.65, 95% CI: 1.90-7.02), congenital malformation of the great vessels (OR: 3.50, 95% CI: 1.10-11.18), congenital defect originating in perinatal period (OR: 4.07, 95% CI: 1.71-9.70), cardiovascular disease (OR: 5.19, 95% CI: 2.77-9.72), neurological disorders (OR: 6.48, 95% CI: 3.76-11.18), blood disease (OR: 3.67, 95% CI: 1.98-6.79), and liver disease (OR: 14.99, 95% CI: 1.49-150.82) contributed to ICU admission in RSV cases.
Using ICD-10-based surveillance data allows to identify risk factors for hospitalized RSV disease and its severe outcomes, and quantify the risk in different age-groups.
呼吸道合胞病毒（RSV）是导致幼儿急性下呼吸道感染住院的主要原因。
我们旨在确定住院 RSV 疾病及其严重结局的危险因素。
我们进行了一项回顾性队列研究，分析了基于 ICD-10 编码的严重急性呼吸道感染（SARI）医院监测的数据。使用单变量和多变量逻辑回归分析，我们评估了年龄组、性别、季节和潜在的医疗状况作为 RSV 及其严重结局（包括 ICU 入院、呼吸机支持应用和死亡）的可能危险因素。
在数据库中因 SARI 住院的 413552 名患者中，从 2009 年第 01 周至 2018 年第 20 周诊断出 8761 例 RSV，其中 97%（8521 例）年龄<5 岁。在<5 岁的儿童中，0-5 个月（OR：20.29，95%CI：18.37-22.41）和 6-12 个月（OR：4.59，95%CI：4.16-5.06）年龄组，以及特定于围产期的呼吸和心血管疾病（OR：1.32，95%CI：1.11-1.57）是诊断为 RSV 的危险因素。0-5 个月年龄组（OR：2.39，95%CI：1.45-3.94）、低出生体重（OR：6.77，95%CI：1.28-35.71）、早产新生儿（OR：6.71，95%CI：2.19-20.61）、特定于围产期的呼吸和心血管疾病（OR：4.97，95%CI：3.36-7.34）、先天性心脏病（OR：3.65，95%CI：1.90-7.02）、大血管先天性畸形（OR：3.50，95%CI：1.10-11.18）、围产期起源的先天性缺陷（OR：4.07，95%CI：1.71-9.70）、心血管疾病（OR：5.19，95%CI：2.77-9.72）、神经疾病（OR：6.48，95%CI：3.76-11.18）、血液疾病（OR：3.67，95%CI：1.98-6.79）和肝脏疾病（OR：14.99，95%CI：1.49-150.82）导致 RSV 病例 ICU 入院。
使用基于 ICD-10 的监测数据可以确定住院 RSV 疾病及其严重结局的危险因素，并量化不同年龄组的风险。
