Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute and Bio-X, Stanford University, Stanford, CA, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute and Bio-X, Stanford University, Stanford, CA, USA.
Cell Stem Cell. 2024 Nov 7;31(11):1563-1573. doi: 10.1016/j.stem.2024.09.017. Epub 2024 Oct 24.
Neurodevelopment involves the migration, projection, and integration of various cell types across different regions of the nervous system. Assembloids are self-organizing systems formed by the integration of multiple organoids or cell types. Here, we outline the generation and application of assembloids. We illustrate how assembloids recapitulate critical neurodevelopmental steps, like migration, axon projection, and circuit formation, and how they are starting to provide biological insights into neuropsychiatric disorders. Additionally, we review how assembloids can be used to study properties emerging from cell-cell interactions within non-neural tissues. Overall, assembloid platforms represent a powerful tool for discovering human biology and developing therapeutics.
神经发育涉及各种细胞类型在神经系统不同区域的迁移、投射和整合。组装体是由多个类器官或细胞类型整合形成的自组织系统。在这里，我们概述了组装体的生成和应用。我们举例说明了组装体如何再现关键的神经发育步骤，如迁移、轴突投射和回路形成，以及它们如何开始为神经精神疾病提供生物学见解。此外，我们还回顾了组装体如何用于研究非神经组织中细胞-细胞相互作用产生的特性。总的来说，组装体平台代表了发现人类生物学和开发治疗方法的有力工具。
