Miller G J, Wheeler M J, Price S G, Beckles G L, Kirkwood B R, Carson D C
Atherosclerosis. 1985 Jun;55(3):251-8. doi: 10.1016/0021-9150(85)90104-2.
Serum high-density lipoprotein (HDL) cholesterol, testosterone and sex-hormone-binding globulin (SHBG) were measured in 300 men, aged 35-64 years, of African and Indian descent who represented a 40% sample of participants in a community survey of coronary heart disease in Trinidad. Free testosterone was calculated from total testosterone and SHBG. In 113 men, HDL2 and HDL3 cholesterol were measured by a precipitation technique. Indian men had a significantly lower HDL-cholesterol concentration than African men (P = 0.003), which is known to be due to a reduction in the HDL3 fraction (demonstrable only in younger men in the subsample drawn for this study). Testosterone did not differ with ethnic group, but SHBG was reduced in Indians (P = 0.03). After allowance for age, ethnic group, alcohol consumption and smoking habit, HDL cholesterol was associated positively with SHBG (P = 0.025) but was not related significantly to either total testosterone or its free and bound components. Serum HDL2 cholesterol was associated positively and independently with SHBG (P = 0.001) and total and bound testosterone (P = 0.002), whereas HDL3 cholesterol showed no significant associations with these factors. Neither SHBG or testosterone afforded an explanation for the relatively low HDL and HDL3 cholesterol concentrations in Indian men.
在特立尼达一项冠心病社区调查中，对300名年龄在35至64岁之间、具有非洲和印度血统的男性进行了血清高密度脂蛋白（HDL）胆固醇、睾酮和性激素结合球蛋白（SHBG）的测量。游离睾酮由总睾酮和SHBG计算得出。对113名男性采用沉淀技术测量了HDL2和HDL3胆固醇。印度男性的HDL胆固醇浓度显著低于非洲男性（P = 0.003），已知这是由于HDL3部分减少所致（仅在本研究抽取的子样本中的年轻男性中可证实）。睾酮在不同种族间无差异，但印度人的SHBG降低（P = 0.03）。在考虑年龄、种族、饮酒量和吸烟习惯后，HDL胆固醇与SHBG呈正相关（P = 0.025），但与总睾酮及其游离和结合成分均无显著相关性。血清HDL2胆固醇与SHBG（P = 0.001）以及总睾酮和结合睾酮（P = 0.002）呈正相关且独立相关，而HDL3胆固醇与这些因素无显著关联。SHBG和睾酮均无法解释印度男性HDL和HDL3胆固醇浓度相对较低的原因。
