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通过在饮食中添加含有鲍曼-伯克蛋白酶抑制剂的大豆提取物来预防二甲基肼诱导的小鼠结肠腺瘤性肿瘤。

Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor.

作者信息

Weed H G, McGandy R B, Kennedy A R

出版信息

Carcinogenesis. 1985 Aug;6(8):1239-41. doi: 10.1093/carcin/6.8.1239.

DOI:10.1093/carcin/6.8.1239
PMID:4040444
Abstract

Dimethylhydrazine (DMH) induces adenocarcinomas of the colon and rectum in rodents; this animal cancer model system is thought to closely resemble human colorectal cancer. An extract of soybeans containing the Bowman-Birk protease inhibitor added to the diet of DMH-treated mice resulted in a significant suppression of adenomatous tumors of the colonic mucosa. Non-treated mice maintained on the same diet for most of their natural life-span (1.5 years) showed no observable health problems.

摘要

二甲基肼（DMH）可诱发啮齿动物的结肠和直肠癌；这种动物癌症模型系统被认为与人类结直肠癌极为相似。在经DMH处理的小鼠饮食中添加含有Bowman-Birk蛋白酶抑制剂的大豆提取物，可显著抑制结肠黏膜腺瘤性肿瘤。在其大部分自然寿命（1.5年）中以相同饮食饲养的未处理小鼠未出现明显的健康问题。

相似文献

1
Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor.通过在饮食中添加含有鲍曼-伯克蛋白酶抑制剂的大豆提取物来预防二甲基肼诱导的小鼠结肠腺瘤性肿瘤。
Carcinogenesis. 1985 Aug;6(8):1239-41. doi: 10.1093/carcin/6.8.1239.
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Suppression of dimethylhydrazine-induced carcinogenesis in mice by dietary addition of the Bowman-Birk protease inhibitor.通过在饮食中添加鲍曼-伯克蛋白酶抑制剂抑制二甲基肼诱导的小鼠致癌作用。
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引用本文的文献

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Susceptibility of different mice species to chemical induction of colorectal cancer by 1,2-dimethylhydrazine.不同小鼠品系对1,2 - 二甲基肼化学诱导结直肠癌的易感性。
J Egypt Natl Canc Inst. 2025 Jan 13;37(1):2. doi: 10.1186/s43046-024-00255-x.
2
Feeding of soy protein isolate to rats during pregnancy and lactation suppresses formation of aberrant crypt foci in their progeny's colons: interaction of diet with fetal alcohol exposure.在大鼠怀孕和哺乳期给其喂食大豆分离蛋白可抑制其子代结肠中异常隐窝病灶的形成：饮食与胎儿酒精暴露的相互作用。
J Carcinog. 2004 Oct 15;3(1):14. doi: 10.1186/1477-3163-3-14.
3
Characterization of a proteinase inhibitor from Cajanus cajan (L.).
木豆蛋白酶抑制剂的特性分析。
J Protein Chem. 2003 Aug;22(6):543-54. doi: 10.1023/b:jopc.0000005504.57372.5b.
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Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency.大鼠中最有效的结肠癌化学预防剂：对异常隐窝病灶和肿瘤数据的系统评价，按效力排序。
Nutr Cancer. 2002;43(1):1-21. doi: 10.1207/S15327914NC431_1.
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A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors.C3H/10T1/2细胞中的一种丝氨酸蛋白酶活性，可被抗癌蛋白酶抑制剂抑制。
Proc Natl Acad Sci U S A. 1987 Jul;84(14):4801-5. doi: 10.1073/pnas.84.14.4801.
6
Pyrene acts as a cocarcinogen with the carcinogens benzo[a]pyrene, beta-propiolactone and radiation in the induction of malignant transformation in cultured mouse fibroblasts; soybean extract containing the Bowman-Birk inhibitor acts as an anticarcinogen.芘在诱导培养的小鼠成纤维细胞发生恶性转化过程中，与致癌物苯并[a]芘、β-丙内酯及辐射共同起促癌剂的作用；含有鲍曼-伯克抑制剂的大豆提取物则起抗癌剂的作用。
Cell Biol Toxicol. 1986 Mar;2(1):21-32. doi: 10.1007/BF00117704.
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A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor.一种受生长调节的蛋白酶活性，可被抗癌的鲍曼-伯克蛋白酶抑制剂抑制。
Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3120-4. doi: 10.1073/pnas.89.7.3120.