Ren Minjiang, Shen Yifan, Yuan Ye, Han Zhiyu, Zhong Yun, Liu Shiming
Department of Cardiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, Guangdong, China.
Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, Guangdong, China.
Sci Rep. 2025 May 22;15(1):17831. doi: 10.1038/s41598-025-01848-9.
Abdominal aortic calcification (AAC) and atherosclerosis are prevalent conditions among older adults, and recent research suggests that their association may extend beyond the effects of aging alone. An essential instrument for determining the possibility of cardiovascular disease (CVD) is the cardiometabolic index (CMI), a new lipid-based index sensitive to visceral obesity. However, little has been established about the relationship between CMI and AAC. We examined CMI and AAC data from the National Health and Nutrition Examination Survey (NHANES) conducted in 2013-2014 for this study. The relationship between AAC, severe abdominal aortic calcification (SAAC), and CMI was assessed using multiple linear and logistic regression models. The overall trend was visualized using smoothed curve modeling. Subgroup analyses were conducted to find possible moderating factors. Among the 2704 participants included, those with higher CMI levels exhibited much greater AAC scores and a higher prevalence of SAAC. In model 3, elevated CMI positively correlated with AAC (0.25 (0.09, 0.41)) and with the odds of SAAC (OR = 1.35 (1.09, 1.67)). Participants in the highest CMI quartile had an AAC score that was 0.65 units higher (β = 0.65 (0.26, 1.04)) and an 114% higher risk of SAAC (OR = 2.14 (1.29, 3.54)). Subgroup analyses indicated sex and smoking status significantly modified the relationship between CMI, AAC, and SAAC, while previously diagnosed with congestive heart failure (CHF) and heart attack significantly moderated the association between CMI and AAC. These results imply that greater AAC scores and a higher risk of SAAC are linked to heightened CMI, which represents visceral fat storage and disturbed lipid metabolism. Our findings indicate that CMI is correlated with AAC in certain demographic and cardiovascular subgroups, suggesting its potential as an exploratory indicator of elevated AAC risk in these populations.
腹主动脉钙化（AAC）和动脉粥样硬化在老年人中普遍存在，最近的研究表明，它们之间的关联可能不仅仅局限于衰老的影响。心脏代谢指数（CMI）是一种基于脂质的新指数，对内脏肥胖敏感，是确定心血管疾病（CVD）可能性的重要工具。然而，关于CMI与AAC之间的关系，目前所知甚少。在本研究中，我们检查了2013 - 2014年进行的美国国家健康与营养检查调查（NHANES）中的CMI和AAC数据。使用多元线性和逻辑回归模型评估了AAC、重度腹主动脉钙化（SAAC）与CMI之间的关系。使用平滑曲线模型直观显示总体趋势。进行亚组分析以寻找可能的调节因素。在纳入的2704名参与者中，CMI水平较高的参与者表现出更高的AAC评分和更高的SAAC患病率。在模型3中，CMI升高与AAC呈正相关（0.25（0.09，0.41）），与SAAC的几率呈正相关（OR = 1.35（1.09，1.67））。CMI四分位数最高的参与者的AAC评分高0.65个单位（β = 0.65（0.26，1.04）），SAAC风险高114%（OR = 2.14（1.29，3.54））。亚组分析表明，性别和吸烟状况显著改变了CMI、AAC和SAAC之间的关系，而先前诊断为充血性心力衰竭（CHF）和心脏病发作显著调节了CMI与AAC之间的关联。这些结果意味着更高的AAC评分和更高的SAAC风险与升高的CMI相关，CMI代表内脏脂肪储存和脂质代谢紊乱。我们的研究结果表明，CMI在某些人口统计学和心血管亚组中与AAC相关，表明其在这些人群中作为AAC风险升高的探索性指标的潜力。
