Mao Minyun, Zhou Rimei, Chen Yishu, Wei Jiajun, Lin Mingjian, Li Wencai
Dept. Neurology, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, China.
Dept. Intensive Care Unit, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, China.
Sci Rep. 2025 May 22;15(1):17739. doi: 10.1038/s41598-025-01693-w.
Aneurysmal subarachnoid hemorrhage (aSAH) is a severe cerebrovascular disease.This retrospective two-center cohort study aimed to construct a nomogram model for predicting delayed cerebral ischemia (DCI) in aSAH patients using LASSO- logistic regression. A total of 604 aSAH patients were included. We collected serological indicators of patients at admission. Lasso and multivariate logistic regression analysis and was performed to screen variables and constructed the independent predictors into a nomogram using R language. After LASSO and multivariate logistic regression, Alcoholism, PLT, Na, and APTT were identified as independent risk factors for DCI. A nomogram model was then developed based on these factors. The model showed good predictive performance in both the training set (AUC = 0.703) and the validation set (AUC = 0.633), along with stable calibration and favorable clinical benefits. Alcoholism, PLT, Na, and APTT may be independent predictors of DCI in aSAH patients. This nomogram can potentially help clinicians assess the risk of DCI in aSAH patients at an early stage and implement timely preventive and treatment measures.
动脉瘤性蛛网膜下腔出血(aSAH)是一种严重的脑血管疾病。这项回顾性双中心队列研究旨在使用LASSO逻辑回归构建一个预测aSAH患者延迟性脑缺血(DCI)的列线图模型。共纳入604例aSAH患者。我们收集了患者入院时的血清学指标。进行Lasso和多因素逻辑回归分析以筛选变量,并使用R语言将独立预测因素构建为列线图。经过LASSO和多因素逻辑回归分析,酗酒、血小板计数(PLT)、血钠(Na)和活化部分凝血活酶时间(APTT)被确定为DCI的独立危险因素。然后基于这些因素建立了列线图模型。该模型在训练集(AUC = 0.703)和验证集(AUC = 0.633)中均表现出良好的预测性能,同时具有稳定的校准和良好的临床效益。酗酒、PLT、Na和APTT可能是aSAH患者发生DCI的独立预测因素。该列线图可能有助于临床医生在早期评估aSAH患者发生DCI的风险,并及时采取预防和治疗措施。