Liu Linyu, Weng Qiang, Cai Qing, Yu Xintong, Huang Weibin, Xie Shaohua, Shi Yan, Li Huiting, Zhang Yuxuan, Hu Jianping, Li Mengcheng, Chen Guannan, Wang Ning, Lin Xiang, Fu Ying, Lin Yu
Department of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Department of Radiology of First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
NPJ Parkinsons Dis. 2025 May 22;11(1):134. doi: 10.1038/s41531-025-00971-8.
Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson's disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom severity in 123 PD patients stratified by disease stage. MRI quantified CP volume and PVS, including dilated PVS (dPVS), across brain regions. CP-dPVS correlations were stronger in early-stage PD. Region-specific analyses revealed CP volume was associated with PVS in the midbrain and basal ganglia. CP-dPVS correlations emerged in midbrain, basal ganglia, and centrum semiovale. Correlation matrix and mediation analyses together confirmed that only basal ganglia dPVS was both significantly correlated with motor symptoms and served as a mediator, accounting for 30.52% of the association between CP volume and motor severity. These findings suggest that CP enlargement contributes to motor severity in PD, in part through regional glymphatic dysfunction localized to the basal ganglia.
脉络丛（CP）增大和类淋巴系统功能障碍与神经退行性变有关，但其在帕金森病（PD）中的作用仍不清楚。这项回顾性横断面研究调查了123例按疾病阶段分层的PD患者的CP体积、血管周围间隙（PVS）和运动症状严重程度之间的关联。MRI对全脑各区域的CP体积和PVS进行了量化，包括扩张的PVS（dPVS）。在早期PD中，CP与dPVS的相关性更强。区域特异性分析显示，中脑和基底神经节的CP体积与PVS有关。在中脑、基底神经节和半卵圆中心出现了CP与dPVS的相关性。相关矩阵和中介分析共同证实，只有基底神经节dPVS与运动症状显著相关且起中介作用，占CP体积与运动严重程度之间关联的30.52%。这些发现表明，CP增大在一定程度上通过基底神经节局部的类淋巴系统功能障碍导致PD患者的运动严重程度增加。
