Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239.
Department of Neurosurgery, Aurora St. Luke's Medical Center, Milwaukee, WI 53215.
Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2407246121. doi: 10.1073/pnas.2407246121. Epub 2024 Oct 7.
The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.
该神经胶质淋巴通路在啮齿动物中被定义为一个血管周围间隙（PVS）网络，它有助于将脑脊液（CSF）有组织地分配到脑实质中。迄今为止，尚未在人类中显示出血管周围 CSF 和脑间质液的交换。使用鞘内钆对比增强 MRI，我们表明对比增强的 CSF 通过 PVS 进入实质，支持人类存在神经胶质淋巴通路。
