Liu Caroline, Ghebrehiwet-Kuflom Johanna, Isseroff Roslyn Rivkah, Dahle Sara, Morhenn Vera
University of California Davis School of Medicine, 4610 X St, Sacramento, CA, 95817, USA.
Dermatology Service, VA Northern California, Sacramento VA Medical Center, 10535 Hospital Way, Mather, CA, 95655-4200, USA.
Mol Med. 2025 May 22;31(1):201. doi: 10.1186/s10020-025-01247-w.
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the depletion of dopaminergic neurons in the substantia nigra, leading to hallmark motor symptoms such as bradykinesia, tremor, and rigidity. While the focus of PD has been on motor changes, dermatological changes are also commonly seen and may even precede the neurological symptoms. Individuals with PD may exhibit impaired wound healing, potentially due to dysregulated mechanisms involving epidermal growth factor (EGF) and N-methyl-D-aspartate (NMDA) in keratinocytes. This paper hypothesizes that the potential for impaired wound healing in PD patients is linked to reduced EGFR activity and altered NMDAR subunit expression in keratinocytes, in contrast to the upregulated wound healing seen in conditions like psoriasis, which demonstrates elevated EGFR and changes in NMDAR subunit activity. Furthermore, a potential co-interaction between EGF and NMDA in keratinocytes may further contribute to impaired wound healing. Investigating these signaling mechanisms can improve understanding and management of associated dermatological symptoms. We propose additional studies to quantify differences in rates of wound healing between PD patients and age-matched controls in effort to explore therapeutic targets for enhancing wounding healing in the context of PD.
帕金森病（PD）是一种神经退行性疾病，其特征是黑质中多巴胺能神经元的耗竭，导致诸如运动迟缓、震颤和僵硬等典型运动症状。虽然PD的重点一直放在运动变化上，但皮肤变化也很常见，甚至可能先于神经症状出现。PD患者可能表现出伤口愈合受损，这可能是由于角质形成细胞中涉及表皮生长因子（EGF）和N-甲基-D-天冬氨酸（NMDA）的机制失调所致。本文假设，与银屑病等疾病中观察到的伤口愈合上调（表现为EGFR升高和NMDAR亚基活性变化）相反，PD患者伤口愈合受损的可能性与角质形成细胞中EGFR活性降低和NMDAR亚基表达改变有关。此外，角质形成细胞中EGF和NMDA之间的潜在协同相互作用可能进一步导致伤口愈合受损。研究这些信号机制可以增进对相关皮肤症状的理解和管理。我们建议进行更多研究，以量化PD患者与年龄匹配的对照组之间伤口愈合速率的差异，从而探索在PD背景下促进伤口愈合的治疗靶点。
