Van der Merwe J V, Irsigler U M, Van der Merwe C A
J In Vitro Fert Embryo Transf. 1985 Mar;2(1):46-8. doi: 10.1007/BF01130832.
In a nonhuman primate in vitro fertilization program clomiphene citrate was used to superovulate the chacma baboon Papio ursinus. The antiestrogenic effect of clomiphene citrate was demonstrated locally on the perineal tumescence. In comparing the result of 50 spontaneous cycles and 18 clomiphene citrate-stimulated cycles, there was a statistical significant influence on cycle length and duration and degree of perineal swelling. This inhibitory effect on perineal tumescence of the baboon is another example of a local antiestrogenic effect of this drug. Furthermore, it nullified an important clinical parameter of ensuing ovulation.
在一个非人类灵长类动物体外受精项目中，使用枸橼酸氯米芬对南非大狒狒（Papio ursinus）进行超排卵处理。枸橼酸氯米芬的抗雌激素作用在会阴部肿胀方面得到了局部证实。在比较50个自然周期和18个枸橼酸氯米芬刺激周期的结果时，发现对周期长度、持续时间和会阴部肿胀程度有统计学上的显著影响。这种对狒狒会阴部肿胀的抑制作用是该药物局部抗雌激素作用的另一个例子。此外，它使随后排卵的一个重要临床参数无效。
