van der Merwe J V
S Afr Med J. 1981 Aug 29;60(9):347-9.
The analysis of 157 menstrual in 50 patients on ovulation-inducing regimens showed that in restoring ovulation clomiphene citrate inhibited cervical mucus production and caused hypersecretion of oestradiol. The inhibitory effect was inversely proportional to serum oestradiol levels, and the addition of conjugated oestrogens did not rectify the inhibitory effect, increase plasma oestradiol levels or increase cycle length. Doubling the clomiphene dosage made no significant difference to any of the parameters examined. The mechanism of this inhibitory effect is still obscure.
对50例接受促排卵方案患者的157个月经周期进行分析，结果显示，枸橼酸氯米芬在恢复排卵时会抑制宫颈黏液分泌，并导致雌二醇分泌过多。这种抑制作用与血清雌二醇水平呈反比，添加结合雌激素并不能纠正抑制作用、提高血浆雌二醇水平或延长月经周期。将氯米芬剂量加倍对所检测的任何参数均无显著影响。这种抑制作用的机制仍不清楚。
