Hunt J M, Gerring E L
J Vet Pharmacol Ther. 1985 Jun;8(2):165-73. doi: 10.1111/j.1365-2885.1985.tb00940.x.
Prostaglandin E1 was infused intravenously (25, 50 and 75 ng/kg/min) in three ponies. Changes in gastrointestinal mechanical and electrical activity were recorded from chronically implanted strain-gauge force transducers and electrodes. Dose-dependent responses were obtained: there were significant decreases in electrical spiking activity in the stomach, left large colon and small colon, with a corresponding decrease of activity in the left dorsal colon mechanogram. The small intestine was also affected, showing a decrease in both contraction rate and amplitude, which was more marked in the proximal jejunum than in the ileum. There was an association between these changes in gastrointestinal activity and the presence of discomfort and diminished gut sounds.
在三只小马驹中静脉输注前列腺素E1（25、50和75纳克/千克/分钟）。通过长期植入的应变片式力传感器和电极记录胃肠道机械和电活动的变化。获得了剂量依赖性反应：胃、左大结肠和小结肠的电尖峰活动显著降低，左背结肠肌电图中的活动相应减少。小肠也受到影响，收缩率和幅度均降低，在空肠近端比回肠更明显。胃肠道活动的这些变化与不适和肠鸣音减弱之间存在关联。
