King J N, Gerring E L
Department of Surgery, Royal Veterinary College, North Mymms, Hertfordshire, England.
Equine Vet J. 1991 Jan;23(1):11-7. doi: 10.1111/j.2042-3306.1991.tb02705.x.
Post operative ileus (POI) is a common and serious complication of colic surgery in the horse. There is a high correlation between the incidence of POI and the presence of ischaemic bowel, suggesting a role for endotoxin. 0.1 micrograms/kg endotoxin was administered intravenously to six ponies with chronically implanted gastrointestinal electromechanical recording devices. It produced profound disruption of normal fasting bowel motility patterns, with an inhibition of gastric contraction amplitude and rate, left dorsal colon contraction product and small colon spike rate. In the small intestine an increase in abnormally arranged regular activity and a decrease in irregular activity was observed. There was no significant prolongation in stomach to anus transit time as assessed by the passage of plastic spheres. The bowel motility patterns induced by endotoxin could be mimicked by the intravenous infusion of PGE2 and less potently by PGI2 (prostacyclin), but not by PGF2 alpha. This study provides evidence that systematic endotoxin present in clinical cases of colic may play a role in the pathogenesis of equine ileus. The acute effects of endotoxin on bowel motility appear to be mediated indirectly by prostaglandins, and the inhibitory effects may be mediated mainly by PGE2.
术后肠梗阻（POI）是马属动物结肠手术常见且严重的并发症。POI的发生率与缺血性肠病的存在高度相关，提示内毒素起了一定作用。给6匹植入了慢性胃肠机电记录装置的小马静脉注射0.1微克/千克内毒素。它导致正常禁食时的肠道运动模式严重紊乱，抑制了胃收缩幅度和速率、左背结肠收缩量以及小结肠尖峰速率。在小肠中，观察到异常排列的规律活动增加，不规律活动减少。通过塑料球的通过情况评估，胃到肛门的转运时间没有显著延长。内毒素诱导的肠道运动模式可通过静脉输注前列腺素E2模拟，前列腺素I2（前列环素）的模拟作用较弱，但前列腺素F2α不能模拟。这项研究提供了证据，表明结肠临床病例中存在的全身性内毒素可能在马属动物肠梗阻的发病机制中起作用。内毒素对肠道运动的急性影响似乎由前列腺素间接介导，且抑制作用可能主要由前列腺素E2介导。
