Forghani B, Cremer N E, Johnson K P, Fein G, Likosky W H
Arch Neurol. 1980 Oct;37(10):616-9. doi: 10.1001/archneur.1980.00500590040004.
The CSF from 279 patients with multiple sclerosis (MS), probable MS, or controls was examined by radioimmunoassay (RIA) for antibodies to measles, rubella, mumps, parainfluenza 1 (Sendai) (strain 6/94), herpes simplex (HSV), varicella, and vaccinia viruses. Significantly more patients with MS than noninflammatory control patients had antibody to measles, rubella and varicella viruses, of which antibody to measles was the most prevalent. The percentage of patients with MS with two or more CSF antibodies was significantly greater than that in the controls. There was no tendency for certain antibodies to be associated. There was a general relationship between presence of CSF antibodies and severity of MS. The data support the hypothesis of local CNS antibody synthesis of several viral antibodies; however, such local synthesis may be a random event, possibly dependent on the number and specificity of peripheral virus antibody-forming lymphocytes available for ingress into the CNS.
采用放射免疫分析法（RIA）检测了279例多发性硬化症（MS）患者、疑似MS患者或对照者的脑脊液，以检测其针对麻疹、风疹、腮腺炎、副流感1型（仙台）（6/94株）、单纯疱疹病毒（HSV）、水痘病毒和牛痘病毒的抗体。与非炎症对照患者相比，MS患者中针对麻疹、风疹和水痘病毒的抗体明显更多，其中麻疹抗体最为普遍。有两种或更多脑脊液抗体的MS患者百分比显著高于对照组。不存在某些抗体相关的趋势。脑脊液抗体的存在与MS的严重程度之间存在一般关系。这些数据支持几种病毒抗体在中枢神经系统局部合成的假说；然而，这种局部合成可能是一个随机事件，可能取决于可进入中枢神经系统的外周病毒抗体形成淋巴细胞的数量和特异性。
