Han Jian, Wang Ying, Mu Hanlin, Liu Jingmei
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Pathology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Med (Lausanne). 2025 May 8;12:1561231. doi: 10.3389/fmed.2025.1561231. eCollection 2025.
Synchronous neoplasms of the stomach are uncommon. Here we presented an unusual case with coexistence of neuroendocrine tumor and signet ring cell carcinoma in the stomach. Gastroscopic examination of a 66-year-old male patient showed a submucosal tumor-like mass with an ulcer on the surface located in the anterior wall of the lower segment of gastric body, confirmed by subsequent biopsy as a signet ring cell carcinoma. Moreover, we also found a slightly yellowish 6-mm protrusion simulating a polyp located in the lesser curvature of the upper segment of gastric body, and biopsy revealed it was a neuroendocrine tumor. The patient underwent a total gastrectomy with a standard D2 lymph node dissection. Pathohistological results led to the final diagnosis of synchronous neoplasms in the stomach, including a signet ring cell carcinoma and a neuroendocrine tumor.
胃同步性肿瘤并不常见。在此，我们报告了一例罕见病例，胃内同时存在神经内分泌肿瘤和印戒细胞癌。一名66岁男性患者的胃镜检查显示，胃体下段前壁有一个类似黏膜下肿瘤的肿块，表面有溃疡，后续活检确诊为印戒细胞癌。此外，我们还在胃体上段小弯侧发现一个略呈淡黄色、大小为6毫米的类似息肉的隆起，活检显示为神经内分泌肿瘤。该患者接受了标准D2淋巴结清扫的全胃切除术。病理组织学结果最终诊断为胃同步性肿瘤，包括印戒细胞癌和神经内分泌肿瘤。
