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感染所致急性横贯性脊髓炎:一例报告及文献复习

Acute transverse myelitis caused by infection: a case report and review of the literature.

作者信息

Wen Zhiguo, Chen Meiqiu, Xia Cong, Sun Yawei, Zhang Yifan

机构信息

School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

出版信息

Front Med (Lausanne). 2025 May 8;12:1506201. doi: 10.3389/fmed.2025.1506201. eCollection 2025.

Abstract

Acute transverse myelitis (ATM) is a rare but severe neurological disorder that can be triggered by infections, autoimmune conditions, or other factors. While the association between parasitic infections and ATM is uncommon, infection can cause significant neurological damage, posing a diagnostic challenge. We report the case of a 65-year-old male patient who developed acute limb weakness, sensory loss, and fever following abdominal pain. Initial diagnostic tests were inconclusive; however, advanced imaging and metagenomic sequencing of cerebrospinal fluid ultimately confirmed an infection. After treatment with praziquantel, the patient successfully regained substantial motor function. This case highlights the need to consider parasitic infections in endemic areas and demonstrates the critical role of advanced diagnostic tools, such as metagenomic sequencing, in achieving timely diagnosis and treatment, ultimately improving the patient's prognosis.

摘要

急性横贯性脊髓炎(ATM)是一种罕见但严重的神经系统疾病,可由感染、自身免疫性疾病或其他因素引发。虽然寄生虫感染与ATM之间的关联并不常见,但感染可导致严重的神经损伤,带来诊断挑战。我们报告了一例65岁男性患者的病例,该患者在腹痛后出现急性肢体无力、感觉丧失和发热。初步诊断检查结果不明确;然而,脑脊液的高级影像学检查和宏基因组测序最终确诊为感染。在用吡喹酮治疗后,患者成功恢复了大量运动功能。该病例强调了在流行地区考虑寄生虫感染的必要性,并证明了宏基因组测序等先进诊断工具在实现及时诊断和治疗、最终改善患者预后方面的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea5/12094980/09eed335839c/fmed-12-1506201-g001.jpg

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