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提取物通过调节炎症和离子通道活性减轻酵母聚糖诱导的肠易激综合征症状。

extracts alleviate zymosan-induced irritable bowel syndrome symptoms by modulating inflammation and ion channel activity.

作者信息

Choi Na Ri, Choi Woo-Gyun, Park Joon, Kim Yun Tai, Nam Joo Hyun, Kim Byung Joo

机构信息

Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea.

Division of Functional Food Research, Korea Food Research Institute, Wanju-gun, Republic of Korea.

出版信息

Anim Cells Syst (Seoul). 2025 May 20;29(1):360-371. doi: 10.1080/19768354.2025.2507327. eCollection 2025.

DOI:10.1080/19768354.2025.2507327
PMID:40406596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12096662/
Abstract

extracts (SBE) have demonstrated potential therapeutic effects against gastrointestinal disorders. This study evaluated the effects of SBE on zymosan-induced irritable bowel syndrome (IBS) symptoms and the underlying mechanisms involved. The major components of SBE, baicalin and baicalein, were quantified using high-performance liquid chromatography. SBE inhibited pacemaker potentials in interstitial cells of Cajal in vitro, with an IC₅₀ value of 27.48 μg/mL. In an animal model of IBS, SBE administration restored colonic length, weight, and stool consistency. Furthermore, SBE reduced tumor necrosis factor-α expression and alleviated pain-associated behaviors. Histological analysis revealed that SBE treatment restored normal colon tissue structure and significantly reduced inflammation. Electrophysiological recordings demonstrated that SBE inhibited the activity of transient receptor potential (TRP) channels, including TRPV1, TRPV4 and TRPA1, as well as voltage-gated sodium channels (NaV1.5), which are associated with visceral pain hypersensitivity. These findings suggest that SBE has therapeutic potential, making it a promising candidate for the management of IBS.

摘要

提取物（SBE）已显示出对胃肠道疾病的潜在治疗作用。本研究评估了SBE对酵母聚糖诱导的肠易激综合征（IBS）症状及其潜在机制的影响。使用高效液相色谱法对SBE的主要成分黄芩苷和黄芩素进行了定量。SBE在体外抑制了Cajal间质细胞中的起搏电位，IC₅₀值为27.48μg/mL。在IBS动物模型中，给予SBE可恢复结肠长度、重量和粪便稠度。此外，SBE降低了肿瘤坏死因子-α的表达并减轻了疼痛相关行为。组织学分析显示，SBE治疗恢复了正常的结肠组织结构并显著减轻了炎症。电生理记录表明，SBE抑制了瞬时受体电位（TRP）通道的活性，包括TRPV1、TRPV4和TRPA1，以及与内脏疼痛超敏反应相关的电压门控钠通道（NaV1.5）。这些发现表明SBE具有治疗潜力，使其成为治疗IBS的有前景的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/7e617c1628a3/TACS_A_2507327_F0009_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/fa38c8ba0249/TACS_A_2507327_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/bc9fa88b4f38/TACS_A_2507327_F0002_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/aec48624cad6/TACS_A_2507327_F0003_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/6f4af0b353d6/TACS_A_2507327_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/932b8b133b95/TACS_A_2507327_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/39dce9038a22/TACS_A_2507327_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/f12f7d6fd235/TACS_A_2507327_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/3710ee0c8163/TACS_A_2507327_F0008_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/7e617c1628a3/TACS_A_2507327_F0009_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/fa38c8ba0249/TACS_A_2507327_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/bc9fa88b4f38/TACS_A_2507327_F0002_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/aec48624cad6/TACS_A_2507327_F0003_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/6f4af0b353d6/TACS_A_2507327_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/932b8b133b95/TACS_A_2507327_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/39dce9038a22/TACS_A_2507327_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/f12f7d6fd235/TACS_A_2507327_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/3710ee0c8163/TACS_A_2507327_F0008_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3814/12096662/7e617c1628a3/TACS_A_2507327_F0009_OB.jpg

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本文引用的文献

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Irritable bowel syndrome remains a complex disorder of gut-brain interaction: Too many actors on stage.肠易激综合征仍然是一种肠道与大脑相互作用的复杂疾病：涉及的因素太多。
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Lacidophilin tablets relieve irritable bowel syndrome in rats by regulating gut microbiota dysbiosis and intestinal inflammation.
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Quality of life, functional impairment and healthcare experiences of patients with irritable bowel syndrome in Norway: an online survey.挪威肠易激综合征患者的生活质量、功能障碍及医疗保健体验：一项在线调查
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Attention in irritable bowel syndrome: A systematic review of affected domains and brain-gut axis interactions.肠易激综合征中的注意力：对受影响领域及脑-肠轴相互作用的系统评价
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Efficacy of Probiotics in the Management of Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.益生菌在肠易激综合征管理中的疗效：一项系统评价与荟萃分析。
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Efficacy of Amitriptyline in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.阿米替林治疗肠易激综合征的疗效：一项系统评价与荟萃分析。
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