Pellegrino Raffaele, Gravina Antonietta Gerarda
Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples 80138, Italy.
World J Gastroenterol. 2025 Feb 28;31(8):101357. doi: 10.3748/wjg.v31.i8.101357.
The recent study published in the examines the interplay among the neuroendocrine axis, gut microbiota, inflammatory markers, and gastrointestinal symptoms in irritable bowel syndrome (IBS). By integrating all these factors into a single study, this approach reflects the modern concept of functional gastrointestinal disorders as disorders of the gut-brain interaction to be approached in a multiparametric manner, also incorporating non-gastroenterological elements and extending evaluations to parameters related to the neuroendocrine axis. This invited letter to the editor summarizes the main results of the aforementioned study and highlights its multiparametric approach, including variables not strictly gastroenterological, in the study of IBS, and discusses its strengths and limitations.
最近发表在《 》上的一项研究探讨了肠易激综合征（IBS）中神经内分泌轴、肠道微生物群、炎症标志物和胃肠道症状之间的相互作用。通过将所有这些因素整合到一项研究中，这种方法反映了功能性胃肠疾病的现代概念，即作为一种需要以多参数方式处理的肠-脑相互作用障碍，还纳入了非胃肠病学因素，并将评估扩展到与神经内分泌轴相关的参数。这封给编辑的特邀信总结了上述研究的主要结果，强调了其在IBS研究中的多参数方法，包括并非严格意义上胃肠病学的变量，并讨论了其优点和局限性。
