Hemangioblastomas with cystic stromal cell nuclei.

Clearing of stromal cell nuclei were found in two of a series of nine cases of hemangioblastoma. The contents of the clear zones were often positive for lipoprotein by immunoperoxidase staining which suggested that the contents originated from the cytoplasm. Cytoplasmic invagination was not observed but is probable; some vacuoles had a "bubbly" appearance similar to the lipid-laden cytoplasm. The finding of these variations in two of nine cases suggests that cystic change in stromal cell nuclei may not be uncommon in hemangioblastomas.