Shimura T, Hirano A, Llena J F
Acta Neuropathol. 1985;67(1-2):6-12. doi: 10.1007/BF00688119.
Five cases of hemangioblastoma were studied by electron microscopy with particular attention to the stromal cells and their surrounding structures. Most of the stromal cells of the tumor had abundant clear cytoplasm containing rough endoplasmic reticulum, mitochondria, scattered fibrils, and large lipid inclusions. They were usually aggregated without intervening cells. In the perivascular areas, their surfaces facing the perivascular collagen were surrounded by basal lamina. Their apposed cell membranes had occasional adhesive devices. Occasional, long, apparently cylindrical processes of the stromal cell cytoplasm were observed in some cases. These processes contained intermediate filaments of undetermined nature and microtubules. In the border zone between the tumor and the surrounding brain, the stromal cells were occasionally surrounded by narrow sheets of dark cell processes containing fibrils and glycogen granules, consistent with astrocytic processes. Altered neuronal elements were also observed in this area.
对五例血管母细胞瘤进行了电子显微镜研究，特别关注基质细胞及其周围结构。肿瘤的大多数基质细胞具有丰富的透明细胞质，其中含有粗面内质网、线粒体、散在的原纤维和大的脂质包涵体。它们通常聚集在一起，中间没有细胞。在血管周围区域，其面向血管周围胶原的表面被基膜包围。它们相邻的细胞膜偶尔有粘着装置。在某些病例中，偶尔观察到基质细胞细胞质有长的、明显呈圆柱形的突起。这些突起含有性质未明的中间丝和微管。在肿瘤与周围脑组织的边界区域，基质细胞偶尔被含有原纤维和糖原颗粒的深色细胞突起窄片包围，这与星形胶质细胞突起一致。在该区域也观察到了改变的神经元成分。
