Bozzola M, Chirico G, Chiara A, Gasparoni A, Schimpff R M
Acta Paediatr Scand. 1985 Jul;74(4):534-8. doi: 10.1111/j.1651-2227.1985.tb11024.x.
Thymidine Activity (TA) was measured by the effect of serum upon incorporation of 3H-thymidine into human lectin-activated lymphocytes in 54 newborns: 32 full-term, 11 pre-term and 11 with intra-uterine growth retardation (IGR). Capillary blood was collected at 0-6 hours, with routine samplings. TA values were lower in preterm (0.476 +/- 0.079 U/ml) than in IGR (0.910 +/- 0.118 U/ml, p less than 0.01) and in full-term neonates (1.237 +/- 0.60, p less than 0.001), and also in IGR newborns than in newborns of normal weight (p less than 0.025). In preterm neonates TA was significantly correlated with gestational age (r = 0.715, p less than 0.02), but no such correlation existed in IRG and full-term neonates. When TA values were plotted against birth weight, a correlation was found in preterm (r = 0.715, p less than 0.02) and in IGR newborns (r = 0.714, p less than 0.02), but not in full-term neonates. Longitudinal study up to 21 days did not show significant changes in full-term newborns, while in preterm and IGR neonates TA increased progressively to reach normal values at the 21st day. The correlations observed in newborns between TA, birth weight and gestational age, and the postnatal normalization in newborns with low birth weight, show that TA directly reflects the nutritional state of the fetus.
通过血清对54名新生儿人凝集素激活淋巴细胞中3H-胸腺嘧啶核苷掺入的影响来测量胸腺嘧啶核苷活性（TA）：32名足月儿、11名早产儿和11名宫内生长受限（IGR）儿。在0 - 6小时采集毛细血管血，进行常规采样。早产儿的TA值（0.476±0.079 U/ml）低于IGR儿（0.910±0.118 U/ml，p<0.01）和足月儿（1.237±0.60，p<0.001），IGR新生儿的TA值也低于正常体重新生儿（p<0.025）。在早产儿中，TA与胎龄显著相关（r = 0.715，p<0.02），但在IGR儿和足月儿中不存在这种相关性。当将TA值与出生体重作图时，在早产儿（r = 0.715，p<0.02）和IGR新生儿（r = 0.714，p<0.02）中发现有相关性，但在足月儿中未发现。对足月儿长达21天的纵向研究未显示出显著变化，而早产儿和IGR新生儿的TA逐渐升高，在第21天达到正常值。新生儿中观察到的TA、出生体重和胎龄之间的相关性，以及低出生体重新生儿出生后的正常化，表明TA直接反映了胎儿的营养状况。
