Inada Y, Hagiwara H, Kojima S, Shimonaka M, Saito Y
Biochem Biophys Res Commun. 1985 Jul 16;130(1):182-7. doi: 10.1016/0006-291x(85)90399-7.
A hitherto unknown synergism exerted by retinol (vitamin A) and L-ascorbic acid (vitamin C) was discovered using endothelial cells. Retinol stimulated the extracellular and intracellular activities of plasminogen activator up to approximately 8- and 4-fold from the control values, respectively. L-Ascorbic acid enhanced the extracellular and intracellular activities up to approximately 1.5-fold. Above all it was demonstrated that their effects on extracellular activity were synergistic; simultaneous administration of these two vitamins enhanced the extracellular activity up to a 20- to 50-fold. Synthesis of plasminogen activator induced with vitamins A and C was inhibited by a protein synthesis inhibitor, cycloheximide.
利用内皮细胞发现了视黄醇（维生素A）和L-抗坏血酸（维生素C）之间一种前所未知的协同作用。视黄醇分别使纤溶酶原激活剂的细胞外和细胞内活性比对照值提高了约8倍和4倍。L-抗坏血酸使细胞外和细胞内活性提高了约1.5倍。最重要的是，已证明它们对细胞外活性的作用是协同的；同时给予这两种维生素可使细胞外活性提高20至50倍。维生素A和C诱导的纤溶酶原激活剂的合成受到蛋白质合成抑制剂环己酰亚胺的抑制。
