Rossato Francesco, Porsio Andrea, Cecchin Diego, Atzori Matteo, Basile Anna Maria, Zoccarato Marco
Neurology Unit, Ospedale Sant'Antonio, Azienda Ospedale Università di Padova, 35218 Padua, Italy.
Nuclear Medicine Unit, Department of Medicine-DIMED, Azienda Ospedale Università di Padova, 35128 Padua, Italy.
NeuroSci. 2025 May 15;6(2):43. doi: 10.3390/neurosci6020043.
Limbic encephalitis (LE) associated with anti-LGI1 antibodies is an autoimmune disorder characterized by memory decline, behavioral changes, and temporal lobe epilepsy. Faciobrachial dystonic seizures (FBDS) are a hallmark symptom, often preceding cognitive and psychiatric issues. This report presents an 80-year-old male with LGI1 encephalitis, initially manifesting as FBDS. A lung adenocarcinoma was diagnosed two months after the onset of neurological symptoms. Clinical and paraclinical data, including MRI and [18]FDG PET imaging, are described. The patient responded to immunotherapy, including steroids and plasma exchange, along with tumor resection. Following treatment, neurological symptoms resolved, except for mild anxiety and apathy. Further research is needed to determine whether LGI1 encephalitis may occasionally have a paraneoplastic origin, potentially influencing screening and management strategies.
与抗LGI1抗体相关的边缘叶脑炎（LE）是一种自身免疫性疾病，其特征为记忆力减退、行为改变和颞叶癫痫。面臂肌张力障碍性发作（FBDS）是一个标志性症状，通常先于认知和精神问题出现。本报告介绍了一名80岁男性，患有LGI1脑炎，最初表现为FBDS。神经症状出现两个月后诊断出肺腺癌。描述了包括MRI和[18]FDG PET成像在内的临床和副临床数据。患者对包括类固醇和血浆置换在内的免疫疗法以及肿瘤切除术有反应。治疗后，除了轻度焦虑和冷漠外，神经症状均得到缓解。需要进一步研究以确定LGI1脑炎是否偶尔可能有副肿瘤起源，这可能会影响筛查和管理策略。
