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使用二代测序技术对一名感染性休克患者支气管肺泡灌洗液和外周血中的 进行鉴定:病例报告及文献综述。 (原文中“Identification of in...”部分有缺失内容)

Identification of in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review.

作者信息

Liu Weipeng, Su Mengting, Zhang Dongjing, Liu Siqi, Zhang Yin, Yang Zhengfei

机构信息

Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

Cellular & Molecular Diagnostics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

出版信息

Emerg Microbes Infect. 2025 Dec;14(1):2511133. doi: 10.1080/22221751.2025.2511133. Epub 2025 Jun 3.

Abstract

We present a case report of a 59-year-old male diagnosed with pancreatic cancer with multiple abdominal metastases, in whom metagenomic next-generation sequencing unexpectedly identified genomic sequences in both bronchoalveolar lavage fluid and peripheral blood specimens. Subsequent examination further confirmed the presence of viable eggs in the stool samples. The findings underscore the prognostic significance of enhanced diagnostic protocols for parasitic infections in oncological cases. This investigation demonstrates the clinical utility of molecular diagnostic approaches and alternative biological specimens for detecting infection.

摘要

我们报告一例59岁男性胰腺癌伴多发腹部转移的病例,在该患者的支气管肺泡灌洗液和外周血标本中,宏基因组下一代测序意外鉴定出基因组序列。随后的检查进一步证实粪便样本中存在活卵。这些发现强调了在肿瘤病例中加强寄生虫感染诊断方案的预后意义。本研究证明了分子诊断方法和替代生物标本在检测感染方面的临床实用性。

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本文引用的文献

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