福斯高林和罂粟碱对青蛙坐骨神经神经传导的抑制作用被河豚毒素部分阻断。
Inhibitory effects of forskolin and papaverine on nerve conduction partially blocked by tetrodotoxin in the frog sciatic nerve.
作者信息
Ribeiro J A, Sebastião A M
出版信息
Br J Pharmacol. 1985 May;85(1):309-13. doi: 10.1111/j.1476-5381.1985.tb08861.x.
The effects of forskolin, sodium fluoride and papaverine on compound action potentials were investigated in de-sheathed sciatic nerve preparations of the frog. Forskolin decreased in a concentration-dependent manner the amplitude of compound action potentials when nerve conduction was partially blocked by tetrodotoxin (TTX). In the presence of TTX a 50% decrease in the action potential amplitude recorded was obtained with about 2.5 microM forskolin. Sodium fluoride did not modify the amplitude of compound action potentials partially blocked by TTX. Papaverine also decreased the amplitude of compound action potentials partially inhibited by TTX. A 50% decrease in the action potential amplitude recorded in the presence of TTX was obtained with about 10 microM papaverine. The possibility that cyclic AMP modulates axonal excitability by interfering with the entry of sodium through the TTX-sensitive sodium channel is discussed.
在青蛙去鞘坐骨神经标本中研究了福斯高林、氟化钠和罂粟碱对复合动作电位的影响。当神经传导被河豚毒素（TTX）部分阻断时，福斯高林以浓度依赖的方式降低复合动作电位的幅度。在TTX存在的情况下，约2.5微摩尔的福斯高林可使记录到的动作电位幅度降低50%。氟化钠不会改变被TTX部分阻断的复合动作电位的幅度。罂粟碱也会降低被TTX部分抑制的复合动作电位的幅度。在TTX存在的情况下，约10微摩尔的罂粟碱可使记录到的动作电位幅度降低50%。本文讨论了环磷酸腺苷通过干扰钠经TTX敏感钠通道的内流来调节轴突兴奋性的可能性。
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