Billioti de Gage Sophie, Peyre Hugo, Chalumeau Martin, Mikaeloff Yann, Zureik Mahmoud, Weill Alain
EPI-PHARE, Epidemiology of Health Products (French National Agency for the Safety of Medicines and Health Products and French National Health Insurance), Saint-Denis, France.
Centre de Ressources Autisme Languedoc-Roussillon et Centre d'Excellence sur l'Autisme et les Troubles Neuro-développementaux (CeAND), CHU Montpellier, Montpellier, France.
JAMA Netw Open. 2025 May 1;8(5):e2512262. doi: 10.1001/jamanetworkopen.2025.12262.
In most countries, children in the same grade can be up to 12 months apart in age, which represents a considerable relative age difference, particularly in the early years. A relative age effect has been frequently reported in the diagnosis and treatment of attention-deficit/hyperactivity disorder and, more rarely, in the diagnosis of other neurodevelopmental disorders. The relative age effect has never been studied for speech therapy, which is frequently prescribed to treat specific language and learning disorders.
To quantify the association of relative age with the initiation of speech therapy.
DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from the French National Health Data System and included all children born in France between 2010 and 2016 from September of the year of their 5th birthday until July of the year of their 10th birthday or July 31, 2022 (end of study).
Children were categorized according to month of birth.
Risk of speech therapy initiation was estimated using Cox models adjusted for other known risk factors.
In total, 4 188 985 children (mean [SD] age, 5.2 [0.3] years; 50.8% girls) were included. Speech therapy was initiated for 692 086 children (incidence rate, 53.1 per 1000 person-years, 54.5% boys) during a mean (SD) follow-up of 3.1 (1.6) years. Among children of the same schooling level, the risk of initiating speech therapy steadily increased according to quarter and month of birth, with adjusted hazard ratios of 1.51 (95% CI, 1.50-1.52) for children born in the last quarter vs the first quarter and 1.64 (95% CI, 1.62-1.66) for children born in December vs those born in January. The relative age effect observed for speech therapy was of the same magnitude as that observed for methylphenidate in attention-deficit/hyperactivity disorder (positive control outcome). No relative age effect was observed for the initiation of desmopressin for nocturnal enuresis (negative control outcome).
This cohort study found that among children in the same grade, an age difference of a few months was associated with the frequency of initiation of speech therapy. These findings may be attributable to a mismatch between the expectations of the school system and the relative age and level of maturity of the children or earlier identification of neurodevelopmental disorders in the youngest children in each age group.
在大多数国家,同一年级的儿童年龄相差可达12个月,这代表着相当大的相对年龄差异,尤其是在早年。注意缺陷多动障碍的诊断和治疗中经常报告相对年龄效应,而在其他神经发育障碍的诊断中相对较少。言语治疗方面从未研究过相对年龄效应,而言语治疗常用于治疗特定语言和学习障碍。
量化相对年龄与言语治疗开始之间的关联。
设计、设置和参与者:这项队列研究使用了法国国家卫生数据系统的数据,纳入了2010年至2016年在法国出生的所有儿童,从他们5岁生日当年的9月到10岁生日当年的7月或2022年7月31日(研究结束)。
根据出生月份对儿童进行分类。
使用针对其他已知风险因素进行调整的Cox模型估计开始言语治疗的风险。
总共纳入了4188985名儿童(平均[标准差]年龄为5.2[0.3]岁;50.8%为女孩)。在平均(标准差)3.1(1.6)年的随访期间,692086名儿童开始接受言语治疗(发病率为每1000人年53.1例,54.5%为男孩)。在同一年级的儿童中,开始言语治疗的风险根据出生季度和月份稳步增加,最后一个季度出生的儿童与第一季度出生的儿童相比,调整后的风险比为1.51(95%置信区间,1.50 - 1.52),12月出生的儿童与1月出生的儿童相比,调整后的风险比为1.64(95%置信区间,1.62 - 1.66)。言语治疗中观察到的相对年龄效应与注意缺陷多动障碍中哌甲酯治疗的相对年龄效应大小相同(阳性对照结果)。夜间遗尿使用去氨加压素治疗的开始未观察到相对年龄效应(阴性对照结果)。
这项队列研究发现,在同一年级的儿童中,几个月的年龄差异与言语治疗开始的频率相关。这些发现可能归因于学校系统的期望与儿童的相对年龄和成熟水平不匹配,或者每个年龄组中最年幼的儿童神经发育障碍被更早识别。