Roemeling R V, Christiansen N P, Hrushesky W J
J Clin Oncol. 1985 Sep;3(9):1273-6. doi: 10.1200/JCO.1985.3.9.1273.
Sixteen of 26 patients given 51 courses of treatment of the doxorubicin and cisplatin combination with no antiemetic therapy suffered the same number of vomiting episodes and had the same duration of vomiting as did the remaining ten patients given 20 cycles of this chemotherapy plus the standard high-dose metoclopramide regimen. This antiemetic regimen caused significant side effects in one fifth of the patients receiving it.
26名患者接受了51个疗程的阿霉素和顺铂联合治疗且未进行止吐治疗，其中16名患者的呕吐发作次数和呕吐持续时间与其余10名接受20个周期这种化疗加标准高剂量甲氧氯普胺方案的患者相同。这种止吐方案在接受治疗的五分之一患者中引起了显著的副作用。
