Senn H J, Glaus A, Bachmann-Mettler I
J Clin Oncol. 1984 Apr;2(4):320-2. doi: 10.1200/JCO.1984.2.4.320.
Repeated oral doses of metoclopramide (50 mg) and prednisone (25 mg) completely prevented nausea and vomiting (N + V) in approximately 50% and substantially reduced N + V in an additional 27%-36% of 56 chemotherapy courses in 30 consecutive cancer patients who were receiving primarily cisplatin. Toxicity from this antiemetic regimen was minor. Simple oral N + V-prevention with metoclopramide and prednisone is as effective but less cumbersome and considerably less expensive than either high doses of intravenous corticosteroids and/or intravenous metoclopramide.
对30例主要接受顺铂治疗的连续癌症患者的56个化疗疗程进行研究，重复口服甲氧氯普胺（50毫克）和泼尼松（25毫克）可使约50%的患者完全预防恶心和呕吐（N+V），并使另外27%-36%的患者的N+V显著减少。这种止吐方案的毒性较小。与高剂量静脉注射皮质类固醇和/或静脉注射甲氧氯普胺相比，单纯口服甲氧氯普胺和泼尼松预防N+V同样有效，但操作更简便，成本也低得多。
