Tsegay Etsay Weldekidan, Hailu Nigus Alemu, Mengesha Meresa Berwo, Gufue Zenawi Hagos
Department of Modern and Traditional Medicine Research, Tigray Health Research Institute, Mekele, Ethiopia
Department of Biomedical Sciences, Adigrat University, Adigrat, Tigray, Ethiopia.
BMJ Open. 2025 May 23;15(5):e096551. doi: 10.1136/bmjopen-2024-096551.
Healthy dietary choices have an important role in preventing chronic diseases such as cardiovascular disease (CVD). Increasing evidence suggests micronutrient intake (essential minerals and vitamins) is associated with abdominal aortic calcification (AAC), which is an advanced marker of CVD. However, the existing reports seem inconsistent. Some studies reported micronutrients are associated with a lower risk of AAC, while others have reported an increased risk. Therefore, this systematic review and meta-analysis sought to summarise the available evidence on the association of dietary micronutrient intake on AAC.
A comprehensive systematic search of the PubMed/MEDLINE, EMBASE, Web of Science and Google Scholar databases from their inception up to September 1, 2024, will be conducted. All clinical studies that report eligible exposure/s (dietary micronutrient intake) and outcome/s (presence/severity of AAC) will be included, and this systematic review and meta-analysis protocol will be reported following the revised Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. The risk of bias for observational studies will be assessed using the Newcastle-Ottawa Scale and publication bias will be evaluated through visual inspection of funnel plots and the Egger's and Begg's regression tests. The Der Simonian and Laird random-effects model meta-analysis will be calculated to provide pooled results, and the weighted risk ratio with their 95% confidence intervals will be presented.
The results will be disseminated through publishing in a peer-reviewed journal and public presentations at relevant local, national and international conferences, workshops and symposiums. Ethical approval is not required as this is a systematic review of publicly available data.CRD42024575902.
健康的饮食选择在预防心血管疾病（CVD）等慢性疾病中起着重要作用。越来越多的证据表明，微量营养素摄入（必需矿物质和维生素）与腹主动脉钙化（AAC）有关，腹主动脉钙化是心血管疾病的一个晚期标志物。然而，现有报告似乎并不一致。一些研究报告称微量营养素与较低的腹主动脉钙化风险相关，而其他研究则报告风险增加。因此，本系统评价和荟萃分析旨在总结关于饮食中微量营养素摄入与腹主动脉钙化之间关联的现有证据。
将对PubMed/MEDLINE、EMBASE、科学网和谷歌学术数据库从创建到2024年9月1日进行全面的系统检索。所有报告符合条件的暴露因素（饮食中微量营养素摄入）和结果（腹主动脉钙化的存在/严重程度）的临床研究都将被纳入，并且本系统评价和荟萃分析方案将按照修订后的系统评价和荟萃分析方案的首选报告项目指南进行报告。将使用纽卡斯尔 - 渥太华量表评估观察性研究的偏倚风险，并通过漏斗图的视觉检查以及埃格检验和贝格检验评估发表偏倚。将计算Der Simonian和Laird随机效应模型荟萃分析以提供汇总结果，并呈现加权风险比及其95%置信区间。
研究结果将通过在同行评审期刊上发表以及在相关的地方、国家和国际会议、研讨会和座谈会上进行公开演讲来传播。由于这是对公开可用数据的系统评价，因此无需伦理批准。CRD42024575902。
