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Sarcoplasmic reticulum membrane of rat skeletal muscle is disordered with chronic alcohol ingestion.

作者信息

Ohnishi S T, Waring A J, Fang S R, Horiuchi K, Ohnishi T

出版信息

Membr Biochem. 1985;6(1):49-63. doi: 10.3109/09687688509065442.

DOI:10.3109/09687688509065442
PMID:4041005
Abstract

Heavy sarcoplasmic reticulum (SR) was prepared from skeletal muscle of chronic alcoholic rats and control rats. Compared with control rat SR, the SR prepared from alcoholic rats is leakier to Ca2+ and has a lower level of maximum storable Ca2+. With in vitro exposure to ethanol, the Ca2+ release of alcoholic rat SR was not enhanced as much as that of SR prepared from control rats. By using the spin-probes 5-, 7-, 12-, and 16-doxylstearic acid, the disordering effect of ethanol on the SR membrane was studied. The results suggest that SR membrane of chronic alcoholic rats is less ordered than that of control rats even in the absence of in vitro ethanol. However, chronic SR membrane shows a greater resistance to the disordering effect of in vitro addition of ethanol than control rat SR.

摘要

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引用本文的文献

1
Maintenance of structural and functional characteristics of skeletal-muscle mitochondria and sarcoplasmic-reticular membranes after chronic ethanol treatment.慢性乙醇处理后骨骼肌线粒体和肌浆网膜结构与功能特征的维持
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):565-73. doi: 10.1042/bj2740565.