Chen Xiaohang, Wan Lei, Wang Bei
Institute of Hepatobiliary Diseases of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
Sci Rep. 2025 May 23;15(1):18032. doi: 10.1038/s41598-025-01871-w.
The implementation of early mobilization in postoperative care has been shown to expedite patient recovery. However, its widespread use among patients undergoing glioma resection is not firmly established. This study aimed to implement an early mobilization protocol in glioma patients and evaluate its effects on early recovery and long-term prognosis. Patients who underwent craniotomy for glioma treatment between January 2018 and December 2019 were enrolled in a randomized controlled trial comparing conventional perioperative care (control group) with conventional care plus a structured early mobilization protocol (experimental group). We collected data on early recovery and long-term prognosis from patients' electronic health records. Means and frequencies were evaluated using the Mann-Whitney U test, T-test, and chi-square test. The research team conducted standardized assessments in advance to ensure consistency. Postoperative primary outcomes revealed that the experimental group showed improvements of 39.06 points in activities of daily living and 0.86 points in numerical rating scale scores for pain, a 2.02 day shorter mean length of hospital stay (95% confidence interval [CI] 91.099-100.596, 0.403-1.691, 9.754-15.060, P < 0.001). Secondary outcomes also indicated that the experimental group had a 4.2 day shorter mean time to ambulation, a 3.48 day shorter mean duration of central venous catheter use, a 4.15 day shorter mean duration of gastric tube use, and a 3.64 day shorter mean duration of urethral catheter use. Furthermore, the experimental group demonstrated a significantly lower incidence of postoperative complications and reduced hospitalization expenses (P < 0.05). However, no statistically significant differences with secondary outcomes were observed in intraoperative blood loss or three-year prognosis between the two groups. Our findings show that an early mobilization protocol can promote early recovery in patients undergoing glioma resection without adversely affecting long-term prognosis. The protocol demonstrated both safety and cost-effectiveness, supporting its clinical implementation to improve postoperative functional recovery.
术后护理中实施早期活动已被证明可加速患者康复。然而，其在胶质瘤切除患者中的广泛应用尚未得到确凿证实。本研究旨在对胶质瘤患者实施早期活动方案，并评估其对早期康复和长期预后的影响。将2018年1月至2019年12月期间接受开颅手术治疗胶质瘤的患者纳入一项随机对照试验，比较传统围手术期护理（对照组）与传统护理加结构化早期活动方案（试验组）。我们从患者的电子健康记录中收集了早期康复和长期预后的数据。使用曼-惠特尼U检验、T检验和卡方检验评估均值和频率。研究团队提前进行了标准化评估以确保一致性。术后主要结果显示，试验组在日常生活活动方面提高了39.06分，疼痛数字评定量表评分提高了0.86分，平均住院时间缩短了2.02天（95%置信区间[CI]91.099 - 100.596, 0.403 - 1.691, 9.754 - 15.060, P < 0.001）。次要结果还表明，试验组平均下床活动时间缩短了4.2天，中心静脉导管使用平均时长缩短了3.48天，胃管使用平均时长缩短了4.15天，尿管使用平均时长缩短了3.64天。此外，试验组术后并发症发生率显著降低且住院费用减少（P < 0.05）。然而，两组在术中出血量或三年预后方面与次要结果无统计学显著差异。我们的研究结果表明，早期活动方案可促进胶质瘤切除患者的早期康复，且不会对长期预后产生不利影响。该方案显示出安全性和成本效益，支持其在临床中实施以改善术后功能恢复。
