Xiao Tianyichen, Wu Caiming, Huang Yuxuan, Zheng Fangping, Li Nafen, Yan Weihong, Li Chengyao, He Qida, Hong Wenbin, Wu Siqi, Li Yulong, Wang Songqing, Zhang Lei, Liu Changqin, Lin Tianwei, Chen Xueqin
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen University, Xiamen, China.
Cancer Research Center of Xiamen University, Xiamen, China.
Sci Rep. 2025 May 23;15(1):18019. doi: 10.1038/s41598-025-03215-0.
Patients of type 2 diabetes mellitus (T2DM) were grouped into subtypes by a symptom-based diagnostic system of the traditional Chinese medicine for detecting metabolomic information that would otherwise be lost due to the high degree of variations in clinical samples. LC/MS-based metabolomic tools were employed to identify distinct metabolomic features in T2DM patients in one of the subtypes in the symptom-based diagnostic system. Several of the affected metabolic pathways could be ameliorated by the combined treatment of metformin and DPP4 inhibitor, except the taurine/hypotaurine metabolic pathway. It was possible that modulating the taurine/hypotaurine metabolism in the combined treatment with metformin and DPP4 inhibitor would enhance the therapeutic effects. To this end, a mouse diabetic model was treated with taurine in addition to metformin and DPP4 inhibitor. Indeed supplementing taurine during the combined treatment led to improvements in various indicators of the disorder such as those for the fatty acid and glucose metabolisms. It could be concluded that taurine was a useful supplement for treating T2DM with metformin and DPP4 inhibitor.
2型糖尿病（T2DM）患者通过中医基于症状的诊断系统进行分组，以检测代谢组学信息，否则由于临床样本的高度变异性，这些信息将会丢失。基于液相色谱/质谱联用的代谢组学工具被用于识别基于症状的诊断系统中某一亚型的T2DM患者独特的代谢组学特征。除了牛磺酸/亚牛磺酸代谢途径外，二甲双胍和二肽基肽酶4（DPP4）抑制剂联合治疗可改善一些受影响的代谢途径。在二甲双胍和DPP4抑制剂联合治疗中调节牛磺酸/亚牛磺酸代谢可能会增强治疗效果。为此，除了二甲双胍和DPP4抑制剂外，还用牛磺酸治疗小鼠糖尿病模型。事实上，在联合治疗期间补充牛磺酸可改善该疾病的各种指标，如脂肪酸和葡萄糖代谢指标。可以得出结论，牛磺酸是二甲双胍和DPP4抑制剂治疗T2DM的有用补充剂。
