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Photodynamic treatment without verteporfin in chronic central serous chorioretinopathy.

作者信息

Batu Oto Bilge, Kılıçarslan Oğuzhan, Sert Seda, Yetik Hüseyin

机构信息

Department of Ophthalmology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, İstanbul, 34098, Fatih, Turkey.

Department of Ophthalmology, Ayancık State Hospital, Sinop, Turkey.

出版信息

BMC Ophthalmol. 2025 May 23;25(1):310. doi: 10.1186/s12886-025-04144-2.


DOI:10.1186/s12886-025-04144-2
PMID:40410675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12100924/
Abstract

PURPOSE: The purpose of this study was to evaluate the clinical and optical coherence tomography (OCT) results of a newly proposed technique to treat chronic central serous chorioretinopathy (cCSR) and to determine its efficacy in cCSR treatment. This technique is termed photostatic treatment (PST). STUDY DESIGN: A prospective study which includes 44 eyes of 38 patients were treated with PST and followed up for at least 24 months. METHODS: PST was performed by administering light energy delivered to the area using a 689 nm diode laser. PST was performed using the conventional fluence rate (60 J/cm) with a conventional irradiation time of 83 s. Each patient was treated with 3 consecutive laser applications. The primary outcome measures were complete resolution of subretinal fluid and improvement in best-corrected visual acuity (BCVA). RESULTS: The median central macular thickness (CMT) was significantly lower at the final visit after treatment than the initial presentation (median CMT 332,5µ versus 234µ, p < 0.001). Complete resolution of the fluid at the last visit could be achieved in 31 (70.4%) eyes with a significant improvement in median BCVA (p < 0.001). CONCLUSION: The application of laser treatment without a photosensitizing agent proved effective in controlling cCSR, and we propose the term 'photostatic treatment' for this new technique.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/a4a04c200d55/12886_2025_4144_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/d77aa8962947/12886_2025_4144_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/7d4942f28503/12886_2025_4144_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/6c0c9b8222e2/12886_2025_4144_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/a4a04c200d55/12886_2025_4144_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/d77aa8962947/12886_2025_4144_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/7d4942f28503/12886_2025_4144_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/6c0c9b8222e2/12886_2025_4144_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12100924/a4a04c200d55/12886_2025_4144_Fig4_HTML.jpg

相似文献

[1]
Photodynamic treatment without verteporfin in chronic central serous chorioretinopathy.

BMC Ophthalmol. 2025-5-23

[2]
Microperimetric changes and fixation stability status after half-dose photodynamic therapy for chronic central serous chorioretinopathy.

Eur J Ophthalmol. 2020-9

[3]
COMPARISON OF PHOTODYNAMIC THERAPY USING HALF-DOSE OF VERTEPORFIN OR HALF-FLUENCE OF LASER LIGHT FOR THE TREATMENT OF CHRONIC CENTRAL SEROUS CHORIORETINOPATHY.

Retina. 2017-2

[4]
Photodynamic therapy for chronic central serous chorioretinopathy: a 4-year follow-up study.

Retina. 2013-2

[5]
Visual and anatomical evaluation of navigated subthreshold micropulse laser versus photodynamic therapy in managing chronic central serous chorioretinopathy.

Graefes Arch Clin Exp Ophthalmol. 2025-2

[6]
Half-fluence photodynamic therapy in acute central serous chorioretinopathy.

Retina. 2012

[7]
Half-dose photodynamic therapy followed by diode micropulse laser therapy as treatment for chronic central serous chorioretinopathy: evaluation of a prospective treatment protocol.

Acta Ophthalmol. 2016-3

[8]
Half-fluence photodynamic therapy in chronic central serous chorioretinopathy.

Retina. 2013-2

[9]
Randomized Clinical Trial to Compare Micropulse Photocoagulation Versus Half-dose Verteporfin Photodynamic Therapy in the Treatment of Central Serous Chorioretinopathy.

Ophthalmic Surg Lasers Imaging Retina. 2015-9

[10]
Half-time photodynamic therapy in treatment of chronic central serous chorioretinopathy.

Graefes Arch Clin Exp Ophthalmol. 2018-11

本文引用的文献

[1]
Central serous chorioretinopathy: A review.

Clin Exp Ophthalmol. 2023-4

[2]
Central Serous Chorioretinopathy - an Overview.

Klin Monbl Augenheilkd. 2021-9

[3]
Long-term follow-up of chronic central serous chorioretinopathy after successful treatment with photodynamic therapy or micropulse laser.

Acta Ophthalmol. 2021-11

[4]
One-year results of half-dose versus one-third-dose photodynamic therapy in chronic or recurrent central serous chorioretinopathy.

BMC Ophthalmol. 2021-1-12

[5]
Comparison of half-dose versus half-fluence versus standard photodynamic therapy in chronic central serous chorioretinopathy.

Photodiagnosis Photodyn Ther. 2021-3

[6]
Photodynamic Therapy with Verteporfin for Chronic Central Serous Chorioretinopathy: A Review of Data and Efficacy.

Pharmaceuticals (Basel). 2020-10-29

[7]
Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy.

Biomed Res Int. 2020

[8]
Comparing effects of photodynamic therapy in central serous chorioretinopathy: full-dose versus half-dose versus half-dose-half-fluence.

Graefes Arch Clin Exp Ophthalmol. 2019-10

[9]
Central serous chorioretinopathy: Towards an evidence-based treatment guideline.

Prog Retin Eye Res. 2019-7-15

[10]
Half-time photodynamic therapy in treatment of chronic central serous chorioretinopathy.

Graefes Arch Clin Exp Ophthalmol. 2018-11

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