Lin Fa-Chen, Luo Shih-Kai, Tu Hung-Pin, Chuang Hung-Yi, Yang Chen-Cheng, Hung Chih-Hsing
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan.
Department of Occupational and Environmental Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan.
BMC Nephrol. 2025 May 23;26(1):256. doi: 10.1186/s12882-025-04174-4.
Alcohol consumption is linked to varied health outcomes. While alcohol appears to have a protective effect on renal function, the impact on patients with diabetes mellitus (DM) and hypertension (HTN) remains unclear. This cross-sectional observational study aims to explore the association between alcohol use and renal function, particularly for individuals with these comorbidities.
Data from participants in the Taiwan Biobank were analyzed. Participants were divided into drinkers and non-drinkers. Drinkers were defined as an alcohol intake of 150 mL or more per week for at least six months. Renal function was assessed using creatinine levels and 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine for estimated glomerular filtration rate (eGFR). Multivariate multiple regression models were used to examine the relationships between alcohol consumption, DM, HTN, and renal function.
Drinkers had better renal function than non-drinkers, with higher eGFR values and lower creatinine levels. Alcohol consumption was linked to better renal function in DM patients but not HTN patients. A three-way interaction (drinking/DM/HTN) also revealed improved renal function.
This study suggests that alcohol consumption may be associated with better renal function outcomes, particularly in patients with DM and HTN. However, these findings should be interpreted cautiously given the cross-sectional nature of the study. Further longitudinal and mechanistic research is warranted to validate the findings.
Not applicable.
饮酒与多种健康结果相关。虽然酒精似乎对肾功能有保护作用，但对糖尿病（DM）和高血压（HTN）患者的影响仍不清楚。这项横断面观察性研究旨在探讨饮酒与肾功能之间的关联，特别是对于患有这些合并症的个体。
分析了台湾生物银行参与者的数据。参与者被分为饮酒者和非饮酒者。饮酒者定义为每周饮酒量为150毫升或更多，且至少持续六个月。使用肌酐水平和2021年慢性肾脏病流行病学协作组（CKD-EPI）肌酐公式来评估肾功能，以估算肾小球滤过率（eGFR）。使用多变量多元回归模型来研究饮酒、糖尿病、高血压和肾功能之间的关系。
饮酒者的肾功能优于非饮酒者，eGFR值更高，肌酐水平更低。饮酒与糖尿病患者的肾功能改善有关，但与高血压患者无关。三方交互作用（饮酒/糖尿病/高血压）也显示肾功能有所改善。
本研究表明，饮酒可能与更好的肾功能结果相关，特别是在糖尿病和高血压患者中。然而，鉴于本研究的横断面性质，这些发现应谨慎解释。有必要进行进一步的纵向和机制研究以验证这些发现。
不适用。
