Fowler Nicole R, Partrick Katherine A, Taylor James, Hornbecker Michael, Kelleher Kevin, Boustani Malaz, Cummings Jeffrey L, MacLeod Tim, Mielke Michelle M, Brosch Jared R, Lee Janice, Shobin Eli, Galvin James E, Fillit Howard, Udeh-Momoh Chinedu, Willis Deanna R
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Indiana University Center for Aging Research, Indianapolis, Indiana, USA.
J Intern Med. 2025 Jul;298(1):31-45. doi: 10.1111/joim.20098. Epub 2025 May 23.
Primary care is the ideal setting for early detection of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), as it serves as the primary point of care for most older adults. With the growing aging population, reliance on specialists for detection and diagnosis is unsustainable, highlighting the need for primary care-led assessment. Recent research findings on successful brain health prevention strategies, AD diagnostic tools, and anti-amyloid treatments empower primary care to play a central role in early detection and intervention. Primary care-focused resources are being developed, including tools for cognitive assessments and materials designed to educate patients about brain health and initiate discussions on lifestyle modifications, thereby making early detection more feasible and efficient. Identifying risk factors early enables providers to implement interventions that can slow cognitive decline and improve outcomes for patients and caregivers. If left undetected and unmanaged, MCI and ADRD can lead to worse outcomes, including increased falls, hospitalizations, financial vulnerability, and caregiver stress. Early detection enables the identification of reversible causes of cognitive impairment, supports the management of comorbidities worsened by cognitive decline, mitigates safety risks, and can preserve quality of life. Importantly, primary care is essential for addressing ADRD-related health disparities that disproportionately affect racial minorities, rural populations, and those of lower socioeconomic status. With a focus on the United States healthcare system, this perspective addresses how implementing early detection practices into primary care can improve outcomes for patients and caregivers, reduce societal burdens, and promote health equity in ADRD care.
初级保健是早期发现轻度认知障碍(MCI)、阿尔茨海默病及相关痴呆症(ADRD)的理想场所,因为它是大多数老年人的主要医疗保健点。随着老年人口的不断增加,依靠专科医生进行检测和诊断是不可持续的,这凸显了以初级保健为主导进行评估的必要性。最近关于成功的脑健康预防策略、AD诊断工具和抗淀粉样蛋白治疗的研究结果,使初级保健能够在早期检测和干预中发挥核心作用。目前正在开发以初级保健为重点的资源,包括认知评估工具以及旨在教育患者有关脑健康知识并启动关于生活方式改变讨论的材料,从而使早期检测更加可行和高效。早期识别风险因素使医疗服务提供者能够实施干预措施,减缓认知衰退,改善患者和护理人员的结局。如果未被发现和管理,MCI和ADRD可能导致更糟的结局,包括跌倒增加、住院、经济脆弱性增加以及护理人员压力增大。早期检测能够识别认知障碍的可逆原因,支持管理因认知衰退而恶化的合并症,降低安全风险,并可维持生活质量。重要的是,初级保健对于解决ADRD相关的健康差异至关重要,这些差异对少数族裔、农村人口以及社会经济地位较低的人群影响尤为严重。以美国医疗保健系统为重点,本观点阐述了将早期检测实践纳入初级保健如何能够改善患者和护理人员的结局、减轻社会负担并促进ADRD护理中的健康公平。