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Advancing the methodology of clinical trials for aging populations: A call to innovation, inclusion, and global relevance.

作者信息

Marzetti Emanuele, Calvani Riccardo, Coelho-Junior Hélio Jose

机构信息

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168 Rome, Italy.

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168 Rome, Italy.

出版信息

J Nutr Health Aging. 2025 Jun;29(6):100587. doi: 10.1016/j.jnha.2025.100587. Epub 2025 May 23.

DOI:10.1016/j.jnha.2025.100587
PMID:40412138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12172968/
Abstract
摘要

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本文引用的文献

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Enhancing the methodology of clinical trials in older people: A scoping review with global perspective.改进老年人临床试验方法：一项具有全球视野的范围综述
J Nutr Health Aging. 2025 Jun;29(6):100582. doi: 10.1016/j.jnha.2025.100582. Epub 2025 May 14.
2
Participation of Older Adults in Clinical Trials for New Drug Applications and Biologics License Applications From 2010 Through 2019.2010 年至 2019 年新药申请和生物制品许可申请中老年人参与临床试验的情况。
JAMA Netw Open. 2022 Oct 3;5(10):e2236149. doi: 10.1001/jamanetworkopen.2022.36149.
3
Key recommendations from the 2021 "inclusion of older adults in clinical research" workshop.2021年“将老年人纳入临床研究”研讨会的关键建议。
J Clin Transl Sci. 2022 Jan 7;6(1):e55. doi: 10.1017/cts.2022.1. eCollection 2022.
4
Barriers and potential solutions in the recruitment and retention of older patients in clinical trials-lessons learned from six large multicentre randomized controlled trials.在临床试验中招募和留住老年患者的障碍及潜在解决方案：从六个大型多中心随机对照试验中吸取的经验教训。
Age Ageing. 2021 Nov 10;50(6):1988-1996. doi: 10.1093/ageing/afab147.
5
Involving older people in co-designing an intervention to reverse frailty and build resilience.让老年人参与到干预措施的共同设计中，以逆转虚弱和增强适应力。
Fam Pract. 2022 Jan 19;39(1):200-206. doi: 10.1093/fampra/cmab084.
6
Older adult participation in cancer clinical trials: A systematic review of barriers and interventions.老年人参与癌症临床试验：障碍和干预措施的系统评价。
CA Cancer J Clin. 2021 Jan;71(1):78-92. doi: 10.3322/caac.21638. Epub 2020 Oct 1.
7
The COMET Handbook: version 1.0.《COMET手册：第1.0版》
Trials. 2017 Jun 20;18(Suppl 3):280. doi: 10.1186/s13063-017-1978-4.
8
The burden of disease in older people and implications for health policy and practice.老年人的疾病负担及其对卫生政策和实践的影响。
Lancet. 2015 Feb 7;385(9967):549-62. doi: 10.1016/S0140-6736(14)61347-7. Epub 2014 Nov 6.
9
Do we protect or discriminate? Representation of senior adults in clinical trials.我们是在保护还是歧视？老年人在临床试验中的代表性。
Rep Pract Oncol Radiother. 2012 Sep 26;18(1):6-10. doi: 10.1016/j.rpor.2012.08.006. eCollection 2012.
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