Zhuge Deli, Li Li, Sun Xueying, Liang Hui, Jin Chenjie, Lu Ailing, Gao Wenli, Zhong Yutong, Li Wenlu, Chen Sihao, Wang Fang, Yan Linzhi, Meng Weiyang, Lin Xiaoji, Zhang Xufei, Liu Yong, Li Yuanfeng, Zhao Yingzheng, Zhang Xiang, Chen Mengchun, Chen Yijie
Department of Pharmaceutics, School of Pharmaceutical Sciences of Wenzhou Medical University, Wenzhou 325035, China; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo 315302, China.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
J Control Release. 2025 Aug 10;384:113873. doi: 10.1016/j.jconrel.2025.113873. Epub 2025 May 22.
Phototherapy holds great potential for treating cancer and infections but faces limitations related to photosensitizer accumulation, tissue penetration, and diminished photo-conversion efficiency, particularly in deep-seated tumors and infections. Here, a biomimetic phototherapeutic nanodisc platform consisting of erythrocyte membranes and the photosensitizer IR780 is developed. With the advantages of the ultra-small size and exceptional biosafety of cell membrane-derived nanodiscs, this platform facilitates efficient accumulation and deep tissue penetration at disease sites. Upon near-infrared (NIR) irradiation, IR780 delivered via the nanodisc exhibits enhanced photothermal conversion efficiency, markedly inhibiting tumor growth in an orthotopic 4T1 breast cancer model and reducing bacterial load in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection model. Furthermore, the nanodisc platform demonstrates outstanding biocompatibility in mice. In conclusion, this nanodisc system significantly extends the functional potential of cellular nanodiscs, presenting a promising strategy to address the challenges of photosensitizer delivery and biosafety in phototherapeutic applications.
光疗法在治疗癌症和感染方面具有巨大潜力，但面临与光敏剂积累、组织穿透和光转换效率降低相关的限制，特别是在深部肿瘤和感染中。在此，开发了一种由红细胞膜和光敏剂IR780组成的仿生光治疗纳米盘平台。凭借细胞膜衍生纳米盘的超小尺寸和卓越生物安全性的优势，该平台有助于在疾病部位实现高效积累和深部组织穿透。在近红外（NIR）照射下，通过纳米盘递送的IR780表现出增强的光热转换效率，在原位4T1乳腺癌模型中显著抑制肿瘤生长，并在耐甲氧西林金黄色葡萄球菌（MRSA）皮肤感染模型中降低细菌载量。此外，纳米盘平台在小鼠中表现出出色的生物相容性。总之，该纳米盘系统显著扩展了细胞纳米盘的功能潜力，为解决光治疗应用中光敏剂递送和生物安全性挑战提供了一种有前景的策略。
